The photoacoustic effect of near-infrared absorbing porphyrin derivatives prepared via click chemistry
The photoacoustic effect of near-infrared absorbing porphyrin derivatives prepared via click chemistry
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点击化学制备近红外吸收卟啉衍生物的光声效应
DOI：
10.1016/j.dyepig.2017.08.003
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发表时间：
2018
影响因子：
4.5
通讯作者：
He Wanli
中科院分区：
文献类型：
--
作者：
Li Liaoliao;Wang Dong;Wang Lei;Ramella Daniele;Wang Hao;Gao Hong;Zhang Jingjing;Xing Yan;Li Bingnan;Yang Zhou;Cao Hui;He Wanli
近年来，近红外（NIR）吸光剂被用于增强光声（PA）成像和光热治疗（PTT）技术，对近红外（NIR）吸光剂的需求越来越大。在本研究中，仔细研究了一系列近红外吸收卟啉衍生物在PA和PT中的应用。在其他有趣的结果中，发现点击试剂F4-TCNQ的PA强度高于TCNE和TCNQ。当R33分散在水中时，PA强度仍然很高。嵌入脂质体疏水磷脂双层（R33∧L）中的R33分子毒性较低。对近红外染料的系统研究，不仅使近红外吸收染料用于PA信号增强的设计更加合理，而且为降低油溶性有机近红外染料的溶液毒性提供了一条途径。
A great demand of near-infrared (NIR) light-absorbing agents has recently arisen, as they are employed to enhance photoacoustic (PA) imaging and photothermal therapy (PTT) technologies. In this study, applications of a series of NIR absorbing porphyrin derivatives to PA and PT were carefully examined. Among other interesting results, it was found that the click reagent F4-TCNQ showed a higher PA intensity than those of TCNE and TCNQ. Moreover, the PA intensity remained high when R33 was dispersed in water. The toxicity of R33 molecules embedded into hydrophobic phospholipid bilayer of liposomes (R33⊂L) was low. Systematic research of the NIR dyes not only allowed for a more educated design of NIR absorbing dyes for PA signal enhancement, but also provided us with a way to reduce the solution toxicity of oil soluble organic NIR dyes.