Synthesis and biological evaluation of 12 allenic aromatic ethers
Synthesis and biological evaluation of 12 allenic aromatic ethers
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DOI：
10.1016/j.bmcl.2007.02.084
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发表时间：
2007-05-15
影响因子：
2.7
通讯作者：
Fu, Li-Wu
中科院分区：
文献类型：
--
作者：
Wang, San-Yong;Mao, Wei-Wei;Fu, Li-Wu
合成了12个联烯芳香醚类化合物，其中部分化合物是从中国南海的红树林真菌Xylaria sp.2508中分离得到的天然产物。测定了它们对KB和KBv200细胞的抗肿瘤活性。所有这些化合物表现出细胞毒性潜力，从弱到强的活动。构效关系分析表明，丙二烯基的引入可以产生或增强这些酚类化合物的细胞毒性。(c)2007爱思唯尔有限公司保留所有权利。
Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds. (c) 2007 Elsevier Ltd. All rights reserved.