A Versatile and Highly Selective Colorimetric Sensor for the Detection of Amines
A Versatile and Highly Selective Colorimetric Sensor for the Detection of Amines
复制标题
DOI：
10.1002/chem.201700368
复制
发表时间：
2017-03-01
影响因子：
4.3
通讯作者：
de Alaniz, Javier Read
中科院分区：
文献类型：
--
作者：
Diaz, Yvonne J.;Page, Zachariah A.;de Alaniz, Javier Read
报道了Meldrum的活化呋喃（MAF）在溶液、固体载体和蒸汽中亚ppm水平胺的比色检测中的应用。MAF是由廉价和可买到的原料一步合成的，在亲核试剂竞争的情况下对伯胺和仲胺具有高选择性。活化的呋喃和胺之间的反应导致一种明显的颜色变化，肉眼可见。利用紫外/可见吸收光谱法监测溶液中的反应并确定检出限。此外，MAF溶液可用作薄层色谱的染色剂和监测固相合成的多肽和拟肽物。最后，MAF被用于检测从鱼类样品中释放的挥发性胺，展示了食品腐败应用的潜力。
The utility of Meldrum's activated furan (MAF) for the colorimetric detection of sub ppm levels of amines in solution, on solid supports, and as vapors is reported. MAF is synthesized in one step from inexpensive and commercially available starting materials and exhibits high selectivity for primary and secondary amines in the presence of competing nucleophiles. The reaction between activated furans and amines results in a distinct color change, discernable by the naked eye. UV/Vis absorption spectroscopy was utilized to monitor reactions in solution and determine detection limits. Additionally, solutions of MAF were useful as stains for thin layer chromatography and for monitoring solid-phase synthesis of peptides and peptidomimetics. Finally, MAF was used to detect volatile amines released from fish samples, demonstrating potential for food spoilage applications.