Non-coding RNAs and ferroptosis: potential implications for cancer therapy.
Non-coding RNAs and ferroptosis: potential implications for cancer therapy.
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DOI：
10.1038/s41418-022-00998-x
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发表时间：
2022-06
影响因子：
12.4
通讯作者：
Pichler, Martin
中科院分区：
文献类型：
--
作者：
Balihodzic, Amar;Prinz, Felix;Dengler, Michael A.;Calin, George A.;Jost, Philipp J.;Pichler, Martin
铁凋亡是最近定义的调节性细胞死亡的形式，其在生物化学和形态学上不同于传统形式的程序性细胞死亡，例如凋亡或坏死。它是由铁，活性氧和氧化损伤的磷脂驱动的，最终导致线粒体损伤和膜完整性的破坏。许多细胞信号传导途径和分子参与铁凋亡的调节，包括控制细胞氧化还原状态的酶。铁中毒调节网络的改变可能导致包括癌症在内的各种疾病的发展。有证据表明，铁凋亡通常在癌细胞中受到抑制，使它们能够存活和发展。然而，对常见化疗药物具有抗性的癌细胞似乎对铁凋亡诱导剂高度敏感，突出了铁凋亡的药理学调节用于癌症治疗的巨大潜力。非编码RNA（ncRNA）被认为是各种细胞过程的主要调节因子，特别是在癌症中，它们与癌症的所有标志有关。最近的工作也表明它们参与了铁凋亡的分子控制。因此，基于ncRNA的治疗方法代表了调节癌症治疗中铁凋亡的令人兴奋的替代方案。本文综述了参与调节癌症铁凋亡的ncRNA，并根据潜在的治疗应用强调了其潜在的分子机制。
Ferroptosis is a recently defined form of regulated cell death, which is biochemically and morphologically distinct from traditional forms of programmed cell death such as apoptosis or necrosis. It is driven by iron, reactive oxygen species, and phospholipids that are oxidatively damaged, ultimately resulting in mitochondrial damage and breakdown of membrane integrity. Numerous cellular signaling pathways and molecules are involved in the regulation of ferroptosis, including enzymes that control the cellular redox status. Alterations in the ferroptosis-regulating network can contribute to the development of various diseases, including cancer. Evidence suggests that ferroptosis is commonly suppressed in cancer cells, allowing them to survive and progress. However, cancer cells which are resistant to common chemotherapeutic drugs seem to be highly susceptible to ferroptosis inducers, highlighting the great potential of pharmacologic modulation of ferroptosis for cancer treatment. Non-coding RNAs (ncRNAs) are considered master regulators of various cellular processes, particularly in cancer where they have been implicated in all hallmarks of cancer. Recent work also demonstrated their involvement in the molecular control of ferroptosis. Hence, ncRNA-based therapeutics represent an exciting alternative to modulate ferroptosis for cancer therapy. This review summarizes the ncRNAs implicated in the regulation of ferroptosis in cancer and highlights their underlying molecular mechanisms in the light of potential therapeutic applications.
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影响因子：
14.9
作者：
Chorley BN;Campbell MR;Wang X;Karaca M;Sambandan D;Bangura F;Xue P;Pi J;Kleeberger SR;Bell DA
通讯作者：
Bell DA
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
16
作者：
Bosson, Andrew D.;Zamudio, Jesse R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
2.6
作者：
Chen J;Qin C;Zhou Y;Chen Y;Mao M;Yang J
通讯作者：
Yang J