A magnetically modified black phosphorus nanosheet-based heparin delivery platform for preventing DVT accurately
A magnetically modified black phosphorus nanosheet-based heparin delivery platform for preventing DVT accurately
复制标题
磁性修饰的黑磷纳米片肝素递送平台可准确预防DVT
DOI：
10.1039/c9tb01459d
复制
发表时间：
2019
影响因子：
7
通讯作者：
Wang Xiaolei
中科院分区：
文献类型：
--
作者：
Ouyang Huan;Zheng Zhuli;Chen Yutong;Liu Yu;Hong Can;Zhu Yanglong;Deng Jianjian;Ding Xingwei;Zhou Weimin;Wang Xiaolei
A new heparin targeting delivery platform was developed based on iron oxide (Fe3O4) nanoparticles and polyethyleneimine (PEI) functionalized black phosphorus nanosheets (BP NSs). Both in and ex vivo studies suggested that this drug delivery platform (PEI/Fe3O4@BP NSs) possessed high heparin loading capacity (≈450%), accurate magnetic enrichment capacity, and good biocompatibility. With the aid of near-infrared (NIR) laser irradiation, this BP NS based delivery platform could further enhance the photothermal thrombolysis effect. Most importantly, the experiments in vivo confirmed that the proposed PEI/Fe3O4@BP NSs could considerably prolong the effective drug concentration duration of heparin. By which means, accurate, long-acting, and effective thromboprophylaxis could be accomplished with limited drug dosage, which could radically reduce the perniciousness of drug overdose.
