Relationships between auditory event-related potentials and mood state, medication, and comorbid psychiatric illness in patients with bipolar disorder.
Relationships between auditory event-related potentials and mood state, medication, and comorbid psychiatric illness in patients with bipolar disorder.
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DOI：
10.1111/j.1399-5618.2009.00758.x
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发表时间：
2009-12
影响因子：
5.4
通讯作者：
O'Donnell BF
中科院分区：
文献类型：
--
作者：
Fridberg DJ;Hetrick WP;Brenner CA;Shekhar A;Steffen AN;Malloy FW;O'Donnell BF
双相情感障碍(BD)患者在听觉事件相关电位(ERPs)上表现出异常，尽管这些指标与测试时的情绪状态、合并精神疾病、精神病特征的存在以及药物使用之间的关系尚不清楚。本研究的目的是探讨这些因素与BD患者听觉事件相关电位测量之间的关系。采用听觉“古怪”辨别任务，从69例I型BD患者和52例健康对照中诱发事件相关电位。患者根据测试时的情绪状态(心境良好或有症状)被分成不同的组，并使用方差分析比较不同组之间的N100、P200、N200和P300事件相关电位成分的波幅和峰潜伏期。采用多元回归方法研究事件相关电位测量与精神疾病诊断、精神病史和用药状况之间的关系。与健康对照组相比，欣快型和症状型BD患者的P300和P200波幅降低，但不同情绪状态的BD患者的事件相关电位测量结果并无差异。在BD患者中，合并焦虑症的病史与N200峰潜伏期缩短、P300峰潜伏期延长有关。临床变量和事件相关电位测量之间没有显著的其他关系。结果表明，无论BD患者测试时的情绪状态、用药状况或精神病史如何，BD患者的听觉注意力都会受到干扰。这些结果扩展了先前的发现，并为P300事件相关电位的异常作为BD的内表型提供了进一步的证据。
Patients with bipolar disorder (BD) exhibit aberrations in auditory event-related potentials (ERPs), although the relationship between these measures and mood state at testing, comorbid psychiatric illness, presence of psychotic features, and medication usage are unclear. The purpose of this study was to investigate the relationships between these factors and auditory ERP measures in BD patients. An auditory “oddball” discrimination task was used to elicit ERPs from sixty-nine patients with type I BD and 52 healthy controls. Patients were placed into subgroups based upon their mood state at testing (euthymic or symptomatic), and ANOVA was used to compare amplitude and peak latency measures from the N100, P200, N200, and P300 ERP components across subgroups. Multiple regression was used to investigate relationships between ERP measures and comorbid psychiatric diagnosis, history of psychotic features, and medication status. Relative to healthy control participants, euthymic and symptomatic BD patients exhibited reduced P300 and P200 amplitude, but ERP measures did not differ among BD patients on the basis of mood status. A history of a comorbid anxiety disorder was associated with reduced N200 peak latency, but prolonged P300 peak latency among BD patients. No other relationships between clinical variables and ERP measures were significant. The results suggest that disrupted auditory attention may be observed in BD patients regardless of their mood state at testing, medication status, or history of psychosis. These results extend previous findings, and provide further evidence for aberrations in the P300 ERP as an endophenotype for BD.