Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
复制标题
DOI：
10.1038/bjc.1998.312
复制
发表时间：
1998-06
影响因子：
8.8
通讯作者：
Latchman, D S
中科院分区：
文献类型：
--
作者：
Conroy, S E;Sasieni, P D;Amin, V;Wang, D Y;Smith, P;Fentiman, I S;Latchman, D S
热休克蛋白hsp 90，hsp 70和hsp 27在人乳腺癌中的过度表达先前已被证明与总生存率降低相关。此外，在大部分乳腺癌患者的血清中可检测到hsp 90抗体，但在正常对照组中未发现。高抗体水平也与存活率降低相关。在这里，我们表明，抗体热休克蛋白27也可检测到乳腺癌患者的血清中，但不能从正常对照组，而抗体热休克蛋白70检测在两组中的约三分之一。hsp 27抗体的存在与生存率的提高而不是降低相关，特别是在前5年之后。因此，乳腺癌细胞中hsps的过度表达不会引起对所有hsps的全身性免疫应答。此外，不同热休克蛋白抗体的存在与存活率有着明显的关联。这些影响进行了讨论的机制，激发免疫反应的热休克蛋白和这种反应的保护性/非保护性的影响。
The overexpression of the heat-shock proteins hsp90, hsp70 and hsp27 in human mammary carcinomas has previously been shown to correlate with reduced overall survival. Moreover, antibodies to hsp90 were detectable in the serum of a large proportion of breast cancer patients but they were not found in normal controls. High antibody levels also correlated with reduced survival. Here, we show that antibodies to hsp27 were also detectable in the sera from breast cancer patients but not from normal controls, whereas antibodies to hsp70 were detectable in approximately one-third of both groups. The presence of antibodies to hsp27 was correlated with an improved rather than a reduced survival, particularly beyond the first 5 years. Hence, the overexpression of hsps in breast cancer cells does not provoke a generalized immune response to all the hsps. Moreover, the presence of antibodies to different hsps has distinct associations with survival. These effects are discussed in terms of the mechanisms that provoke an immune response to the hsps and the protective/non-protective effects of such a response.