Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study.
Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study.
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DOI：
10.1186/s12903-017-0337-x
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发表时间：
2017-01-16
期刊：
影响因子：
2.9
通讯作者：
Yoshie H
中科院分区：
文献类型：
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作者：
Kakuta E;Nomura Y;Morozumi T;Nakagawa T;Nakamura T;Noguchi K;Yoshimura A;Hara Y;Fujise O;Nishimura F;Kono T;Umeda M;Fukuda M;Noguchi T;Yoshinari N;Fukaya C;Sekino S;Numabe Y;Sugano N;Ito K;Kobayashi H;Izumi Y;Takai H;Ogata Y;Takano S;Minabe M;Makino-Oi A;Saito A;Abe Y;Sato S;Suzuki F;Takahashi K;Sugaya T;Kawanami M;Hanada N;Takashiba S;Yoshie H
牙周炎进展的诊断目前依赖于临床症状（如附着丧失）和放射成像的使用。本文所述的多中心研究的目的是评价从最深的牙周袋中回收的龈下菌斑的细菌含量在评估慢性牙周炎患者疾病进展中的诊断用途。这项研究包括一个为期24个月的调查，共163例慢性牙周炎谁接受了三个月的后续护理。从最深的口袋龈下菌斑回收和评估牙龈卟啉单胞菌，中间普氏菌，放线菌伴聚杆菌的细菌含量使用改良的侵入PLUS测定。使用ELISA测量相应的血清IgG滴度。在24个月的过程中，临床参数的变化进行了评价。计算敏感性、特异性和预测值，并用于确定预测慢性牙周炎进展的临界点。在完成24个月监测阶段的124人中，62人表现出牙周炎进展，而62人表现出稳定的疾病。牙周袋最深处龈下菌斑的牙龈卟啉单胞菌计数与牙周炎的进展显著相关（p < 0.001，阳性预测值= 0.708）。牙周袋最深处龈下菌斑中的牙龈卟啉单胞菌数可能与牙周炎的进展有关。本文的在线版本（doi：10.1186/s12903-017-0337-x）包含补充材料，可供授权用户使用。
The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis. The online version of this article (doi:10.1186/s12903-017-0337-x) contains supplementary material, which is available to authorized users.