Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics.
Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics.
复制标题
神经退行性疾病中神经炎症过程增强以及硝酮作为潜在疗法的作用的证据。
DOI：
10.1007/978-3-7091-6301-6_28
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Bing,G
中科院分区：
文献类型：
--
作者：
Floyd,RA;Hensley,K;Bing,G
Our attempts to explain the serendipitous observations made on the neuroprotective action of a-phenyl-tert-butyl-nitrone (PBN) several years ago provided a challenge, which lead us to postulate the occurrence of neuroinflammatory processes in the stroked and the aging brain to help explain the results. Surprising observations made earlier by other investigators also forced them to conclude that enhanced neuro-inflammatory processes occur in the Alzheimer’s Disease (AD) brain. Observations we made recently, combined with the early seminal findings and the many others made since, overwhelmingly support the notion that neuro-inflammatory processes occur in the AD brain. Results obtained in our attempts to explain the mechanistic basis of the neuroprotective action of PBN provide strong support for the notion that this compound acts, not by trapping free radicals in a mass-action
