Dietary supplementation with the inhibitory amino acid taurine suppresses autotomy in HA rats
Dietary supplementation with the inhibitory amino acid taurine suppresses autotomy in HA rats
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DOI：
10.1097/00001756-199809140-00034
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发表时间：
1998-09-14
期刊：
影响因子：
1.7
通讯作者：
Seltzer, Z
中科院分区：
文献类型：
--
作者：
Belfer, I;Davidson, E;Seltzer, Z
牛磺酸是CNS中的一种抑制性氨基酸。当提供给大鼠时，它在一些急性疼痛试验中产生镇痛作用。在这里，我们研究了牛磺酸补充剂对完整大鼠疼痛敏感性的影响，以及围手术期饮食补充牛磺酸是否会抑制大鼠自切，一种由外周神经切除术产生的与神经病理性疼痛相关的行为。完整大鼠饮用1%牛磺酸饮水2周后，热痛敏感性与对照组无显著差异。在术前、术后或围手术期服用牛磺酸的大鼠中测定的自切水平显著低于匹配的对照组。我们得出结论，牛磺酸在自断模型中起着重要的作用，可能是通过保护中枢神经系统中的抑制性神经元免受损伤放电和异位输入所引发的兴奋性毒性损伤。NeuroReport 9：3103-3107（C）1998 Lippincott威廉姆斯和威尔金斯。
TAURINE is an inhibitory amino acid in the CNS. When supplied to rats it produces analgesia in some acute pain tests. Here we examined the effect of taurine supplementation on sensitivity to pain in intact rats, and whether perioperative dietary supplementation with taurine in rats would suppress autotomy, a behavior produced by peripheral neurectomy and related to neuropathic pain. Thermal pain sensitivity of intact rats consuming 1% taurine in the drinking solution for 2 weeks was not significantly different from that of control rats. Autotomy levels, determined in rats consuming taurine pre-, post- or perioperatively were significantly lower than in matching control groups. We conclude that taurine plays an important role in the autotomy model, presumably by protecting inhibitory neurons in the CNS against an excitotoxic damage triggered by injury discharge and ectopic input from the severed nerves. NeuroReport 9: 3103-3107 (C) 1998 Lippincott Williams & Wilkins.