Differential adhesion in morphogenesis: a modern view
Differential adhesion in morphogenesis: a modern view
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DOI：
10.1016/j.gde.2007.05.002
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发表时间：
2007-08-01
影响因子：
4
通讯作者：
Steinberg, Malcolm S.
中科院分区：
文献类型：
--
作者：
Steinberg, Malcolm S.
一种胚胎组织在另一种胚胎组织上的扩散，它们的细胞在混合时的分选，以及由运动的边缘细胞所遵循的组织间边界的形成，都与不混溶液体的行为相对应。“差异粘附假说”（DAH）解释了这些液体样组织行为的结果产生的组织表面和界面张力所产生的运动细胞之间的粘附能。DAH的实验验证，最近的计算模型模拟粘附介导的形态发生，和证据有关的作用，差异粘附在一些形态动力学事件，包括硬骨鱼epiboly，规范之间的边界菱形在发展中的脊椎动物后脑，上皮间充质转化胚胎，和恶性入侵的证据进行了审查。
The spreading of one embryonic tissue over another, the sorting out of their cells when intermixed and the formation of intertissue boundaries respected by the motile border cells all have counterparts in the behavior of immiscible liquids. The 'differential adhesion hypothesis' (DAH) explains these liquid-like tissue behaviors as consequences of the generation of tissue surface and interfacial tensions arising from the adhesion energies between motile cells. The experimental verification of the DAH, the recent computational models simulating adhesion-mediated morphogenesis, and the evidence concerning the role of differential adhesion in a number of morphodynamic events, including teleost epiboly, the specification of boundaries between rhombomeres in the developing vertebrate hindbrain, epithelial-mesenchymal transitions in embryos, and malignant invasion are reviewed here.