Risk factors for survival and local recurrence after particle radiotherapy for single small hepatocellular carcinoma
Risk factors for survival and local recurrence after particle radiotherapy for single small hepatocellular carcinoma
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DOI：
10.1002/bjs.7397
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发表时间：
2011-04-01
影响因子：
9.6
通讯作者：
Ku, Y.
中科院分区：
文献类型：
--
作者：
Komatsu, S.;Murakami, M.;Ku, Y.
背景：粒子放射治疗是治疗恶性肿瘤的一种新方法。本研究的目的是评估风险因素的总体生存率和局部控制后，粒子放疗的单个小肝癌（HCC），并确定合适的候选人，这种treatment.Methods：2001年和2008年之间的粒子放疗治疗的直径小于5厘米的单个HCC的所有患者进行了回顾性确定从一个前瞻性收集的数据库。结果：共纳入150例患者，其中150例患者的临床结局与预后有关。五年总生存率和局部控制率分别为50.9%和92.3%。多变量分析显示，包括年龄和Child-Pugh分级在内的几个因素对总生存率有显著影响。邻近消化道和Child-Pugh分级是局部复发的独立危险因素。其他肿瘤因素，包括大小，大体分类，以前的治疗，宏观血管浸润，肿瘤位置的隔膜和大血管没有影响局部控制率。结论：粒子放射治疗似乎是安全有效的，可能是一种新的治疗小肝癌。当肿瘤位于肠道附近时，复发更频繁。
Background: Particle radiotherapy is a novel treatment for malignant tumours. The present study aimed to evaluate risk factors for overall survival and local control after particle radiotherapy of single small hepatocellular carcinoma (HCC), and to identify suitable candidates for this treatment.Methods: All patients with a single HCC smaller than 5 cm in diameter treated by particle radiotherapy between 2001 and 2008 were identified retrospectively from a prospectively collected database. Clinical outcomes and prognostic factors were analysed.Results: A total of 150 patients were included. Five-year overall survival and local control rates were 50.9 and 92.3 per cent respectively. Multivariable analysis revealed that several factors, including age and Child-Pugh classification, significantly influenced overall survival. Proximity to the digestive tract and Child-Pugh classification were independent risk factors for local recurrence. Other tumour factors including size, gross classification, previous treatment, macroscopic vascular invasion, and tumour location in relation to the diaphragm and large vessels did not influence local control rate.Conclusion: Particle radiotherapy seems safe and effective, and may be a novel treatment for small HCC. Recurrences are more frequent when the tumour is located close to the gut.