Entropy‐Mediated High‐Entropy MXenes Nanotherapeutics: NIR‐II‐Enhanced Intrinsic Oxidase Mimic Activity to Combat Methicillin‐Resistant Staphylococcus Aureus Infection
Entropy‐Mediated High‐Entropy MXenes Nanotherapeutics: NIR‐II‐Enhanced Intrinsic Oxidase Mimic Activity to Combat Methicillin‐Resistant Staphylococcus Aureus Infection
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熵介导的高熵 MXene 纳米疗法：NIR-II 增强的内在氧化酶模拟活性可对抗耐甲氧西林金黄色葡萄球菌感染
DOI：
10.1002/adma.202211432
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jianliang Shen
中科院分区：
文献类型：
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作者：
Xiaojun He;Yuna Qian;Chenglin Wu;Jiayao Feng;Xiaoshuai Sun;Qinxiang Zheng;Xiaokun Li;Jianliang Shen
细菌性角膜炎（BK）和皮下脓肿等细菌感染对全球医疗保健构成了重大挑战。在这个高耐药性的时代，需要创新和新的抗菌药物和抗菌策略来控制感染。纳米技术正逐渐成为一种经济可行且有效的抗感染治疗方法。高熵MXenes （HE MXenes）用于将活性位点暴露在高熵原子层上，以赋予理想的性质，其在生物医学领域的潜在应用仍有待探索。本文通过引入具有高熵和低吉布斯自由能的过渡金属来制备单层HE MXenes，以填补非高熵MXenes生物催化性能的空白。随着熵的增加，HE MXenes在第二个近红外（NIR - II）生物窗口中具有极强的氧化酶模拟活性（Km = 0.227 mm）和光热转换效率（65.8%）。随后，HE MXenes实现了NIR - II增强的内在氧化酶模拟活性，可杀死耐甲氧西林金黄色葡萄球菌并快速去除生物膜。此外，HE MXenes可以作为纳米治疗剂有效治疗耐甲氧西林金黄色葡萄球菌引起的BK和皮下脓肿感染，且副作用很小。总的来说，单层HE MXenes在治疗耐药细菌感染和促进感染组织愈合方面显示出良好的临床应用潜力。
Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative and new antibacterial agents and antibacterial strategies are in demand to control infections in this era of high drug resistance. Nanotechnology is gradually emerging as an economically feasible and effective anti‐infection treatment. High‐entropy MXenes (HE MXenes) are used to confer desirable properties with exposed active sites to high‐entropy atomic layers, whose potential application in the field of biomedicine remains to be explored. Herein, monolayer HE MXenes are fabricated by implementing transition metals with high entropy and low Gibbs free energy to fill the gap in the biocatalytic performance of non‐high‐entropy MXenes. HE MXenes are endowed with extremely strong oxidase mimic activity (Km = 0.227 mm) and photothermal conversion efficiency (65.8%) in the second near‐infrared (NIR‐II) biowindow as entropy increases. Subsequently, HE MXenes realize NIR‐II‐enhanced intrinsic oxidase mimic activity for killing methicillin‐resistant Staphylococcus aureus and rapidly removing the biofilm. Furthermore, HE MXenes can effectively treat BK and subcutaneous abscess infection induced by methicillin‐resistant Staphylococcus aureus as nanotherapeutic agents with minuscule side effects. Overall, monolayer HE MXenes demonstrate promising clinical application potential in the treatment of drug‐resistant bacterial infections and promote the healing of infected tissues.