Hemodynamic responses of dog lung lobe to lobar venous occlusion.
Hemodynamic responses of dog lung lobe to lobar venous occlusion.
复制标题
狗肺叶对肺叶静脉阻塞的血流动力学反应。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
J. Linehan
中科院分区：
文献类型：
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作者：
T. Hakim;C. Dawson;J. Linehan
我们用恒定流量灌注狗肺的左下叶。当叶静脉流出被阻塞时，叶静脉压力突然上升到低于动脉压力的某个水平，然后动脉和静脉压力开始缓慢上升。对这种反应的一个可能的解释是，当流出被阻塞时，通过床的某些下游段的流动停止。因为流入肺的血流是持续的，所以闭塞后的动静脉压差代表了流经某个上游段的压降，而通过该上游段的血流是持续的。我们将流出道闭塞后的动静脉压差指定为上游压降。将闭塞前的动静脉压差减去上游压降指定为下游压降。为了更好地理解上游和下游压降的含义，我们研究了肺血管收缩和血流方向对上游和下游压降大小的影响。我们还比较了这些压降与发生在叶血管容积中点上游和下游的压降，使用低粘度推注技术。结果表明，上游和下游压降的变化，流出闭塞的评价，反映了叶动脉和静脉阻力的变化。
We perfused the left lower lobe of the dog lung with constant flow. When the lobar venous outflow was occluded, the lobar venous pressure rose suddenly to a level somewhere below the arterial pressure, and then the arterial and venous pressures began to rise more slowly. A possible explanation for this response is that, when the outflow was occluded, flow through some downstream segment of the bed ceased. Because flow into the lung continued, the arteriovenous pressure difference after occlusion represents the pressure drop across some upstream segment through which the flow continued. We designated the arteriovenous pressure difference just after outflow occlusion as the upstream pressure drop. The arteriovenous pressure difference before occlusion minus the upstream pressure drop was designated the downstream pressure drop. In an attempt to better understand the meaning of the upstream and downstream pressure drops, we examined the influence of pulmonary vasoconstriction and flow direction on the size of the upstream and downstream pressure drops. We also compared these pressure drops with the pressure drops occurring upstream and downstream from the midpoint of the lobar vascular volume, using the low-viscosity bolus technique. The results indicate that changes in the upstream and downstream pressure drops, as evaluated by outflow occlusion, reflect changes in the lobar arterial and venous resistances.