Mammalian sirtuins: biological insights and disease relevance.
Mammalian sirtuins: biological insights and disease relevance.
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DOI：
10.1146/annurev.pathol.4.110807.092250
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sinclair DA
中科院分区：
文献类型：
--
作者：
Haigis MC;Sinclair DA
衰老伴随着多个器官系统健康功能的下降，导致II型糖尿病、神经退行性疾病、癌症和心血管疾病等疾病的发病率和死亡率增加。从历史上看，研究人员一直专注于研究孤立器官中的个别通路，以此作为确定疾病根源的策略，并希望能设计出更好的药物。对酵母衰老的研究导致了一类被称为去乙酰化酶（sirtuins）的保守酶家族的发现，这类酶影响多种能延长生物体寿命和提升整体健康的通路。自从10年前发现第一种已知的哺乳动物去乙酰化酶SIRT1以来，我们对去乙酰化酶的酶学、其调节以及它们广泛改善哺乳动物生理机能和健康寿命的能力有了重大进展。这篇综述总结并讨论了过去十年的进展以及未来几年该领域将面临的挑战。
Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular disease. Historically, researchers have focused on investigating individual pathways in isolated organs as a strategy to identify the root cause of a disease, with hopes of designing better drugs. Studies of aging in yeast led to the discovery of a family of conserved enzymes known as the sirtuins, which affect multiple pathways that increase the life span and the overall health of organisms. Since the discovery of the first known mammalian sirtuin, SIRT1, 10 years ago, there have been major advances in our understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and health span. This review summarizes and discusses the advances of the past decade and the challenges that will confront the field in the coming years.
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影响因子：
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作者：
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通讯作者：
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DOI：
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期刊：
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影响因子：
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影响因子：
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