Early-delayed, radiation-induced cognitive deficits in adult rats are heterogeneous and age-dependent.
Early-delayed, radiation-induced cognitive deficits in adult rats are heterogeneous and age-dependent.
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DOI：
10.1667/rr13662.1
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发表时间：
2014-07
影响因子：
3.4
通讯作者：
Riddle DR
中科院分区：
文献类型：
--
作者：
Forbes ME;Paitsel M;Bourland JD;Riddle DR
接受全脑照射治疗的患者通常会出现认知缺陷，这被认为是正常组织损伤造成的。年龄是这些副作用的一个危险因素。我们比较了分段全脑照射（300千伏X射线）对年轻成年和中年大鼠的认知影响。在3个月大的时候，年轻时受辐射的大鼠在物体记忆方面有明显的缺陷，然而，在中年时受辐射的大鼠没有明显的类似缺陷。此外，在分割全脑辐照后的6个月和12个月，年轻人的物体记忆缺陷不再明显，在任何时候，无论辐照时的年龄，在空间记忆任务中都没有检测到辐射引起的缺陷。因此，临床相关的成年大鼠分块全脑照射导致早期延迟的认知变化，这种变化是异质性的、短暂的和年龄依赖性的。当前和以往关于辐射诱导认知变化的研究结果支持对辐射诱导脑损伤啮齿动物模型的持续研究和验证，这对于开发和测试治疗癌症幸存者诱导认知功能障碍的新疗法至关重要。
Patients treated with whole-brain irradiation often develop cognitive deficits that are presumed to result from normal tissue injury. Age is a risk factor for these side effects. We compared the cognitive effects of fractionated whole-brain irradiation (300 kV X rays) in rats irradiated either as young adults or in middle age. A deficit in object memory was apparent at 3 months in rats irradiated as young adults, however, no comparable deficit was apparent in rats irradiated in middle age. In addition, the deficit in object memory in young adults was no longer apparent at 6 and 12 months after fractionated whole-brain irradiation and no radiation-induced deficit was detectable in a spatial memory task at any time, regardless of age at time of irradiation. Thus, clinically relevant fractionated whole-brain irradiation in adult rats resulted in early-delayed cognitive changes that were heterogeneous, transient and age-dependent. The results of the current and previous studies of radiation-induced cognitive changes support the continued investigation and validation of rodent models of radiation-induced brain injury, which are critical for developing and testing new therapies for treatment-induced cognitive dysfunction in cancer survivors.