Distribution of H type 1 and H type 2 antigenic determinants in human sera and saliva.
Distribution of H type 1 and H type 2 antigenic determinants in human sera and saliva.
复制标题
H 1 型和 H 2 型抗原决定簇在人血清和唾液中的分布。
DOI：
--
复制
发表时间：
1982
影响因子：
9.8
通讯作者：
A. Dalix
中科院分区：
文献类型：
--
作者：
LE Jacques;Pendui;R. Lemieux;F. Lambert;A. Dalix
一项针对H型1抗原决定因子的放射免疫分析表明，H型1抗原在血清和唾液中都受到Se基因的严格控制。在Se/-、le/le供者和Se/-、le/ -供者的唾液中发现相似数量的H型1抗原决定因子。然而，Se/-、le/le供者的血清抑制H - 1检测的效率是Se/-、le/ -供者的100倍左右。放射线免疫分析表明，唾液中所有的H型2抗原都受Se基因的控制，而血清中只有三分之一的H型2抗原受Se基因的控制。血清中其余三分之二的H型2抗原与供者的ABH分泌状态无关。血清和唾液中2型H抗原的数量与Le基因无关。这些结果与两种α (1 leading to 2)聚焦基转移酶的存在是一致的，但表明由Se基因编码的上皮源性酶应该能够转化1型和2型天然底物，而由H基因编码的中胚层源性酶则优先作用于天然2型底物。
A radioimmunoassay specific for the H type 1 antigenic determinant demonstrated that the H type 1 antigen is under the strict control of the Se gene in both serum and saliva. Similar amounts of H type 1 antigenic determinants were found in saliva from Se/-, le/le donors and in saliva from Se/-, Le/- donors. However, sera from Se/-, le/le donors were about 100 times more efficient in inhibiting the H type 1 assay than were sera from Se/-, Le/- donors. A radioimmunoassay, based on the binding of Ulex europaeus with the H type 2 antigenic determinant, showed that all the H type 2 antigen in saliva is under the control of the Se gene, while only one-third of the H type 2 antigen present in serum is under the control of this gene. The remaining two-thirds of H type 2 antigen in sera is independent of the ABH secretor status of the donor. The amount of H type 2 antigen in both serum and saliva is independent of the Le gene. These results are compatible with the existence of two alpha (1 leads to 2) fucosyl-transferases but suggest that the enzyme of epithelial origin, coded by the Se gene, should be able to transform both type 1 and type 2 natural substrates, while the enzyme of mesodermic origin, coded by the H gene, would work preferentially on the natural type 2 substrates.
ABH 和 Lewis 组合抗原的淋巴细胞毒性定义及其从血清到淋巴细胞的转移。
影响因子：
2.7
作者：
Oriol,R;Danilovs,J;Lemieux,R;Terasaki,P;Bernoco,D
通讯作者：
Bernoco,D