Listing occupational carcinogens.
Listing occupational carcinogens.
复制标题
DOI：
10.1289/ehp.7047
复制
发表时间：
2004-11
影响因子：
10.4
通讯作者：
Boffetta P
中科院分区：
文献类型：
--
作者：
Siemiatycki J;Richardson L;Straif K;Latreille B;Lakhani R;Campbell S;Rousseau MC;Boffetta P
职业环境一直是研究人类癌症病因学最富有成效的领域。许多公认的人类致癌物都是职业性致癌物。有大量关于不同工作环境中癌症风险的流行病学和实验数据。综合这些信息对科学和公共卫生都很重要。各种组织和个人公布了职业致癌物清单。然而，由于公认的致癌物应被视为职业致癌物的标准不明确，以及关于可能发现致癌物质的职业和行业及其癌症目标部位的信息不一致和不完整，这些清单受到限制。本文主要以国际癌症研究机构发表的评价为基础，并补充了其他信息，试图以表格形式总结目前关于职业致癌物、发现致癌物的职业和行业及其靶器官的知识。我们认为28种物质为确定的职业致癌物，27种物质为可能的职业致癌物，113种物质为可能的职业致癌物。这些表格应有助于监管或预防目的，以及在研究重点确定和了解致癌作用方面的科学目的。
The occupational environment has been a most fruitful one for investigating the etiology of human cancer. Many recognized human carcinogens are occupational carcinogens. There is a large volume of epidemiologic and experimental data concerning cancer risks in different work environments. It is important to synthesize this information for both scientific and public health purposes. Various organizations and individuals have published lists of occupational carcinogens. However, such lists have been limited by unclear criteria for which recognized carcinogens should be considered occupational carcinogens, and by inconsistent and incomplete information on the occupations and industries in which the carcinogenic substances may be found and on their target sites of cancer. Based largely on the evaluations published by the International Agency for Research on Cancer, and augmented with additional information, the present article represents an attempt to summarize, in tabular form, current knowledge on occupational carcinogens, the occupations and industries in which they are found, and their target organs. We have considered 28 agents as definite occupational carcinogens, 27 agents as probable occupational carcinogens, and 113 agents as possible occupational carcinogens. These tables should be useful for regulatory or preventive purposes and for scientific purposes in research priority setting and in understanding carcinogenesis.