Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study
Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study
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DOI：
10.1007/s00417-009-1072-z
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发表时间：
2009-08-01
影响因子：
2.7
通讯作者：
Fry, Christopher H.
中科院分区：
文献类型：
--
作者：
Williamson, Tom H.;Grewal, Jas;Fry, Christopher H.
本初步研究探讨玻璃体切除术对CRVO患者玻璃体腔内PO2的影响。前瞻性、对照、干预性研究。本研究包括6例单眼缺血性CRVO患者（行玻璃体切除合并桡骨视神经切除术，RON）和6例伴有黄斑孔或膜的患者。在玻璃体切除前（玻璃体切除前）和玻璃体切除后（玻璃体切除后）插入氧探针。CRVO患者在RON手术前进行测量。在玻璃体中腔和玻璃体前进行氧合记录（PO2）。平均年龄65岁。在对照组中，玻璃体切除术前，视网膜附近的平均PO2 （15.0 mmHg S.D.5.7）明显低于中腔（33.7 mmHg S.D.12.8）。同样，在CRVO中，玻璃体切除术前视网膜前PO2 （8.1 mmHg s.d.3.5）明显低于中腔（19.8 mmHg S.D.7.3）。CRVO眼的平均PO2明显低于对照眼。玻璃体切除术后，对照组中腔（61.5 mmHg S.D.13.9）和视网膜前（75.8 mmHg s.d.9.1）和CRVO眼中腔（53.7 mmHg s.d.17.9）和视网膜前（59.8 mmHg s.d.15.8）两个记录部位的PO2均显著高于玻璃体切除术前。CRVO患者玻璃体腔内PO2减少。玻璃体切除术可能是一种增加视网膜氧气供应的方法。
In this pilot study the effects of vitrectomy on PO2 in the vitreous cavity in CRVO were investigated.Prospective, controlled, interventional study.Six patients with ischaemic CRVO in one eye (undergoing vitrectomy for radial optic neurotomy, RON) and six with either macula hole or membrane were included. An oxygen probe was inserted before removal of the vitreous (pre-vitrectomy) and after removal of the vitreous (post-vitrectomy). In the patients with CRVO, measurements were taken before RON was performed. Oxygenation recordings (PO2) were taken in the mid-vitreous cavity and the preretinal vitreous.Mean age was 65 years. In controls, pre-vitrectomy, the mean PO2 adjacent to the retina (15.0 mmHg S.D.5.7) was significantly less than mid-cavity (33.7 mmHg S.D.12.8). Similarly in CRVO, the pre-vitrectomy pre-retinal PO2 (8.1 mmHg S.D. 3.5), was significantly less than mid-cavity (19.8 mmHg S.D.7.3). The mean PO2 was significantly less in the eyes with CRVO than in control eyes. Post-vitrectomy, the PO2 was significantly greater than pre-vitrectomy at both recording sites in the controls mid-cavity (61.5 mmHg S.D.13.9) and pre-retinal (75.8 mmHg S.D. 9.1), and CRVO eyes mid-cavity (53.7 mmHg S.D. 17.9) and pre-retinal (59.8 mmHg S.D. 15.8).PO2 is reduced in the vitreous cavity in CRVO. Vitrectomy may be a method of increasing oxygen availability to the retina.