Impact of disease activity on health-related quality of life in systemic lupus erythematosus - a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS).
Impact of disease activity on health-related quality of life in systemic lupus erythematosus - a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS).
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DOI：
10.1186/s12865-017-0200-5
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发表时间：
2017-03-28
期刊：
影响因子：
3
通讯作者：
Swiss Systemic Lupus Erythematosus Cohort Study Group
中科院分区：
文献类型：
--
作者：
Chaigne B;Chizzolini C;Perneger T;Trendelenburg M;Huynh-Do U;Dayer E;Stoll T;von Kempis J;Ribi C;Swiss Systemic Lupus Erythematosus Cohort Study Group
评估疾病活动对系统性红斑狼疮 (SLE) 患者健康相关生活质量 (HRQoL) 的影响。对 2007 年 4 月至 2014 年 6 月期间纳入瑞士 SLE 队列研究的患者进行的横断面研究。HRQoL 结果基于医疗结果研究简表 36 (SF-36)。疾病活动度通过 SLE 疾病活动指数评分、SLE 国家评估修订版中雌激素安全性 (SELENA-SLEDAI) 和医师整体评估 (PGA) 进行评估。在 252 名患者中，207 名 (82%) 是女性。中位[四分位距 (IQR)] 年龄为 43 [32–57] 岁。 125 名患者 (49.6%) 患有 SLE。活动性 SLE 与非活动性 SLE 中的中位 [IQR] 精神成分总结 (MCS) 分别为 40.0 [30.2–51.0] 和 47.3 [39.2–52.8] (p< 0.01)，中位 [IQR] 身体成分总结 (PCS) 为 43.7 [37.0–52.8] 和 49.1 [38.4–55.6]，分别（p < 0.05）。 SELENA-SLEDAI 的增加或 PGA 的增加与 PCS 和/或 MCS 呈负相关。在调整性别、年龄和病程后，疾病活动对 PCS 和 MCS 以及除一般健康之外的所有分量表都有影响。活动性狼疮肾炎和肌肉骨骼受累与身体限制和情绪问题、身体疼痛增加和社会功能差有关。低补体和/或抗 dsDNA 抗体的存在与疲劳增加和心理健康状况下降有关。在 SLE 患者中，活动性疾病患者的 HRQoL 会降低。疾病活动对 HRQoL 维度的影响取决于 SELENA-SLEDAI 系统组件。本文的在线版本 (doi:10.1186/s12865-017-0200-5) 包含补充材料，可供授权用户使用。
To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). Cross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Outcome Study Short Form 36 (SF-36). Disease activity was assessed by the SLE Disease Activity Index score with the Safety of Estrogens in SLE National Assessment modification (SELENA-SLEDAI) and by the physican’s global assessment (PGA). Of the 252 patients included, 207 (82%) were women. Median [interquartile range (IQR)] age was 43 [32–57] years. SLE was active in 125 patients (49.6%). Median [IQR] mental component summary (MCS) in active vs inactive SLE was 40.0 [30.2–51.0] compared to 47.3 [39.2–52.8] (p < 0.01) and median [IQR] physical component summary (PCS) 43.7 [37.0–52.8] compared to 49.1 [38.4–55.6], respectively (p < 0.05). Increase in SELENA-SLEDAI or increase in PGA were negatively correlated with PCS and/or MCS. After adjusting for gender, age and disease duration, disease activity impacted on both PCS and MCS and all subscales except general health. Active lupus nephritis and musculoskeletal involvement were associated with physical limitations and emotional problems, increased bodily pain and poor social functioning. Low complement and/or presence of anti-dsDNA antibodies were associated with increased fatigue and reduced mental health. In patients with SLE, HRQoL is reduced in those with active disease. Impact of disease activity on HRQoL dimensions depends on SELENA-SLEDAI system components. The online version of this article (doi:10.1186/s12865-017-0200-5) contains supplementary material, which is available to authorized users.