On the nature of visible chromosomal gaps and breaks

On the nature of visible chromosomal gaps and breaks
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关于可见染色体间隙和断裂的性质

DOI:
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发表时间:
2004
影响因子:
1.7
通讯作者:
J. Savage
J. Savage
中科院分区:
生物学4区
文献类型:
--
作者:
J. Savage

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从染色体畸变研究的早期开始,光学显微镜观察到的“间隙”和“断裂”的区别、性质和起源一直是争论和争议的话题。在本文中,我们简要地综述了大量文献中出现的各种观点,并试图根据我们目前对染色体结构和畸变形成的理解对它们进行评价。注意G2/S细胞不精确引起的判读问题。
From the earliest days of chromosomal aberration studies, the distinction, nature and origin of light-microscope observed “gaps” and “breaks” have been topics for debate and controversy. In this paper we survey, briefly, the various ideas that have appeared in the very extensive literature, and attempt to evaluate them in the light of our current understanding of chromosome structure and aberration formation. Attention is drawn to the problems of interpretation caused by G2/S cell imprecision.
辐射产生的沿染色体断裂的聚集:模拟对染色体畸变的影响。
DOI: 10.1080/095530099139999
发表时间: 1999
影响因子: 2.6
作者:
Sachs,RK;Chen,AM;Simpson,PJ;Hlatky,LR;Hahnfeldt,P;Savage,JR
通讯作者: Savage,JR