Local circuit for the computation of object approach by an identified visual neuron in the locust
Local circuit for the computation of object approach by an identified visual neuron in the locust
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用于通过蝗虫中已识别的视觉神经元计算物体接近度的局部电路
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
P. Simmons
中科院分区：
文献类型：
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作者：
F. C. Rind;P. Simmons
蝗虫视觉系统中的小叶巨型运动检测器（LGMD）神经元是运动敏感通路的一部分，它检测碰撞过程中接近的物体。在这里，我们表明LGMD突触前的视网膜定位单位直接相互形成突触，并且这些突触紧邻它们到LGMD的输出。突触沿着远端小叶中LGMD的细树突出现，通常数量很多，并完全覆盖LGMD突起。当免疫金标记的单克隆GABA抗体没有特异性标记传入过程时，γ氨基丁酸（GABA）作为这些突触的可能神经递质被消除。我们用组织化学方法证明，乙酰胆碱酯酶，水解乙酰胆碱在胆碱能突触的酶，是存在于之间的视网膜单位和沿着膜的LGMD的突触裂缝。这是公认的，乙酰胆碱具有兴奋和抑制作用，我们建议，这些retinotopic单位兴奋LGMD，但抑制对方，和突触形成的边缘移动到连续的光感受器引起的兴奋和抑制横向传播之间的关键比赛的基板。这导致对在碰撞过程中接近的物体的选择性响应。J.Comp.神经元395：405 - 415，1998.© 1998 Wiley利斯公司
The lobula giant movement detector (LGMD) neuron in the locust visual system is part of a motion‐sensitive pathway that detects objects approaching on a collision course. Here we show that the retinotopic units presynaptic to the LGMD make synapses directly with each other and these synapses are immediately adjacent to their outputs onto the LGMD. Synapses occur along the fine dendrites of the LGMD in the distal lobula, often in large numbers and completely covering the LGMD processes. Gamma aminobutyric acid (GABA) was eliminated as a possible neurotransmitter at these synapses when immunogold‐tagged monoclonal GABA antibody did not specifically label the afferent processes. We used a histochemical method to demonstrate that acetylcholine esterase, the enzyme that hydrolyses acetylcholine at cholinergic synapses, was present in the synaptic clefts between the retinotopic units and along the membrane of the LGMD. It is well established that acetylcholine has both excitatory and inhibitory effects and we propose that these retinotopic units excite the LGMD, but inhibit each other; and that the synapses form the substrate for a critical race between excitation caused by edges moving out over successive photoreceptors, and inhibition spreading laterally. This results in the selective response to objects approaching on a collision course. J. Comp. Neurol. 395:405–415, 1998. © 1998 Wiley‐Liss, Inc.
突触前抑制控制动作电位向轴突末梢传播的计算机研究。
影响因子：
2.5
作者：
Segev,I
通讯作者：
Segev,I