Pathogenesis of aortic stenosis and its relation to age.
Pathogenesis of aortic stenosis and its relation to age.
复制标题
主动脉瓣狭窄的发病机制及其与年龄的关系。
DOI：
10.1136/hrt.34.6.569
复制
发表时间：
1972
影响因子：
--
通讯作者：
A. Pomerance
中科院分区：
文献类型：
--
作者：
A. Pomerance
在患有孤立性主动脉瓣狭窄的成人III型心脏的IO8中，如果在检查中包括对上述未打开的瓣膜的检查，则可以通过肉眼确定发病机制。钙化的先天性二尖瓣是最常见的发现（43%），其特征是一个横向裂缝样或新月形的开口。大多数患者为男性。31%的狭窄仅由老年退行性钙化引起，其特征为三辐状开口，无连合粘连。妇女在这一群体中占多数。炎症后（风湿性）连合粘连产生一个固定的中央圆形或三角形孔被发现在24%的情况下，和先天性二尖瓣的一个连合炎症融合在另外的7%.The相对频率不同的年龄组这三种病因。在60岁以下的患者中，由于先前的炎性瓣膜疾病导致的狭窄占主导地位，在60至75岁之间的先天性二叶瓣钙化，在75岁以下未观察到退行性钙化，但在该年龄段占主导地位，并且是几乎所有85岁以上孤立性主动脉瓣狭窄病例的原因。
In Io8 of IiI heartsfrom adults with isolated aortic stenosis the pathogenesis could be determined macroscopically if inspection of the unopened valve from above was included in the examination. Calcified congenitally bicuspid valves were the commonest finding (43%) and were characterized by a transverse slit-like or crescentic orifice. The majority ofpatients were men. Senile degenerative calcification alone was responsible for stenosis in 31 per cent. This was characterized by a triradiate orifice without commissural adhesions. Women predominated in this group. Postinflammatory (rheumatic type) commissural adhesions producing a fixed central circular or triangular orifice were found in 24 per cent of cases, and inflammatory fusion of one commissure of a congenitally bicuspid valve in a further 7 per cent. The relative frequency of these three pathogeneses varied in different age groups. Stenosis due to previous inflammatory valve disease predominated in patients under 6o years, calcification in congenitally bicuspid valves between 6o and 75 years, and degenerative calcification was not seen under 75 years, but predominated over this age and was responsible for almost all cases of isolated aortic stenosis over 85 years.