Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia
Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia
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DOI：
10.1016/j.amjhyper.2004.03.666
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Luthy, DA
中科院分区：
文献类型：
--
作者：
Enquobahrie, DA;Williams, MA;Luthy, DA
背景：我们研究了妊娠早期血浆脂质浓度与先兆子痫风险之间的关系。方法：在一项前瞻性队列研究中，平均在妊娠 13 周时采集母体血液样本。我们从队列中选择了 57 名患有先兆子痫的女性和 510 名血压保持正常的女性作为对照对象。通过标准化测定以酶法测量血浆脂质浓度。使用逻辑回归程序来计算调整后的比值比 (OR) 和 95% 置信区间 (0)。 结果：随后发生先兆子痫的女性的 LDL 胆固醇、甘油三酯和 LDL/HDL 比率浓度分别比对照受试者高 10.4%、13.6% 和 15.5% (P < .05)。先兆子痫女性的 HDL 胆固醇浓度比对照组低 7.0% (P < .05)。调整后，总胆固醇>205 mg/dL的女性先兆子痫的风险增加3.60倍（95% Cl 1.23至10.51），甘油三酯水平>133 mg/dL的女性先兆子痫的风险增加4.15倍（95% Cl 1.50至11.49）。随着 LDL 胆固醇、甘油三酯浓度和 LDL/HDL 比率三分位数的增加，观察到先兆子痫风险呈线性增加（所有趋势 P < .05）。结论：早期妊娠血脂异常与先兆子痫风险增加相关。这种关联对于理解先兆子痫的病理过程可能具有重要意义，并且可能有助于制定预防或早期诊断该疾病的策略。 (C) 2004 年美国高血压杂志有限公司。
Background: We investigated the relationship between early pregnancy plasma lipid concentrations and risk of preeclampsia.Methods: In a prospective cohort study, maternal blood samples were collected at an average of 13 weeks gestation. From the cohort, we selected 57 women who developed preeclampsia and 510 who remained normotensive and served as control subjects. Plasma lipid concentrations were measured enzymatically by standardized assays. Logistic regression procedures were used to calculate adjusted odds ratios (OR) and 95% confidence intervals (0).Results: Women who subsequently developed preeclampsia had 10.4%, 13.6%, and 15.5% higher concentrations of LDL cholesterol, triglycerides, and LDL/HDL ratios, respectively, than did control subjects (P < .05). The HDL cholesterol concentrations were 7.0% lower in women with preeclampsia than in control subjects (P < .05). After adjustment, there was a 3.60-fold increase in risk of preeclampsia among women with total cholesterol >205 mg/dL (95% Cl 1.23 to 10.51) and a 4.15-fold increase in the risk of preeclampsia among women with triglyceride levels >133 mg/dL (95% Cl 1.50 to 11.49). A linear increase in preeclampsia risk was observed with increasing tertiles of LDL cholesterol, triglyceride concentrations, and LDL/HDL ratio (all P < .05 for trend).Conclusion: Early pregnancy dyslipidermia is associated with an increased risk of preeclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of the disorder. (C) 2004 American Journal of Hypertension, Ltd.