Evaluation of three-dimensional image registration methodologies for in vivo micro-computed tomography
Evaluation of three-dimensional image registration methodologies for in vivo micro-computed tomography
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DOI：
10.1007/s10439-006-9168-7
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发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Gasser, Juerg S.
中科院分区：
文献类型：
--
作者：
Boyd, Steven K.;Moser, Stephan;Gasser, Juerg S.
体内微计算机断层扫描（micro-CT）的出现为测量个体骨微结构的时间适应性提供了一种新的方法。在连续扫描之间的扫描仪中的空间对齐是具有挑战性的，但三维图像配准可用于叠加结果图像数据，从而确保分析的兴趣区域（ROI）一致。目前已经开发了几种图像配准方法，但对其在高分辨率微ct数据中的应用知之甚少。本研究的目的是探索三种图像配准相似性度量和三种图像插值器的组合，以及多分辨率配准配置，以评估体外和体内微ct数据的计算效率和准确性。通过与基于附加基准标记的金标准参考变换进行比较，评估准确性措施。结论是，在增加图像分辨率的步骤中，使用线性图像插值器的互信息配准相似性度量提供了准确和高效结果之间的最佳折衷。在去卵巢大鼠模型中测量的胫骨微观结构的体内配准提供了一致的ROI，从而证明了三维图像配准对体内实验和临床显微ct研究的有用性。该技术有望成为常用的微ct数据分析技术，以诊断和监测骨病治疗的疗效。
The advent of in vivo micro-computed tomography (micro-CT) provides a novel approach to measure the temporal adaptation of bone micro-architecture within an individual. Spatial alignment in the scanner between serial scans is challenging, but three-dimensional image registration can be used to superimpose the resulting image data, thus ensuring consistent regions of interest (ROI) for analysis. There have been several approaches to image registration developed, yet little is known about their application to high resolution micro-CT data. The purpose of this study was to explore combinations of three image registration similarity measures and three image interpolators, in addition to multi-resolution registration configurations, for assessment of computational efficiency and accuracy on both in vitro and in vivo micro-CT data. Accuracy measures were assessed by comparison with a gold-standard reference transform based on attached fiducial markers. It was concluded that a mutual information registration similarity measure with a linear image interpolator, applied at steps of increasing image resolution, provided the best compromise between accurate and efficient results. In vivo registration of tibial bone microstructure measured in an ovariectomized rat model provided consistent ROI thus demonstrating the usefulness of three-dimensional image registration for in vivo experimental and clinical micro-CT research. It is a technique that is poised to become commonly utilized for analysis of micro-CT data to diagnose and monitor efficacy of therapy in bone diseases.