Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma
Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma
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DOI：
10.1016/j.radonc.2009.01.010
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发表时间：
2009-07-01
影响因子：
5.7
通讯作者：
Ono, Koji
中科院分区：
文献类型：
--
作者：
Suzuki, Minoru;Tanaka, Hiroki;Ono, Koji
背景和目的：为探讨加速器BNCT（accelerator based BNCT，AB-BNCT）治疗肝脏多发性肿瘤和恶性胸膜间皮瘤（malignant pleural mesothelioma，MPM）的可行性，比较AB-BNCT和反应堆BNCT（reactor-based BNCT，RB-BNCT）的剂量分布和照射时间。RB-BNCT上的中子束数据来自京都大学研究反应堆研究所（KURRI）的研究反应堆。结果：在多发性肝肿瘤的BNCT中，以5 Gy-Eq剂量作为对健康肝组织的平均剂量，AB-BNCT和RB-BNCT对肝肿瘤的平均剂量分别为68.1和65.1 Gy-Eq。在MPM的BNCT中，当正常同侧肺的平均肺剂量为5 Gy Eq时，AB-BNCT和RB-BNCT输送到MPM肿瘤的平均剂量分别为20.2和19.9 Gy Eq。剂量分布分析表明，AB-BNCT是上级RB-BNCT治疗深部tumors.Conclusions：AB-BNCT系统的可行性，在我们的研究所构建的BNCT从临床的观点在多个肝脏肿瘤和MPM证实。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。放射治疗和肿瘤学92（2009）89-95
Background and purpose: To confirm the feasibility of accelerator-based BNCT (AB-BNCT) for treatment of multiple liver tumors and malignant pleural mesothelioma (MPM), we compared dose distribution and irradiation time between AB-BNCT and reactor-based BNCT (RB-BNCT).Material and methods: We constructed treatment plans for AB-BNCT and RB-BNCT of four multiple liver tumors and six MPM. The neutron beam data on RB-BNCT were those from the research reactor at Kyoto University Research Reactor Institute (KURRI). The irradiation time and dose-volume histogram data were assessed for each BNCT system.Results: In BNCT for multiple liver tumors, when the 5 Gy-Eq dose was delivered as the mean dose to the healthy liver tissues, the mean dose delivered to the liver tumors by AB-BNCT and RB-BNCT was 68.1 and 65.1 Gy-Eq, respectively. In BNCT for MPM, when the mean lung dose to the normal ipsilateral lung was 5 Gy-Eq, the mean dose delivered to the MPM tumor by AB-BNCT and RB-BNCT was 20.2 and 19.9 Gy-Eq, respectively. Dose distribution analysis revealed that AB-BNCT is Superior to RB-BNCT for treatment of deep-seated tumors.Conclusions: The feasibility of the AB-BNCT system constructed at our institute was confirmed from a clinical viewpoint in BNCT for multiple liver tumors and MPM. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 92 (2009) 89-95