Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease
Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease
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DOI：
10.1111/j.1601-183x.2008.00453.x
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Rivest, S.
中科院分区：
文献类型：
--
作者：
Filali, M.;Lalonde, R.;Rivest, S.
神经精神症状在阿尔茨海默病患者的初级护理中至关重要，但在小鼠模型中却相对被忽视。在本研究中，通过触摸逃逸测试，APPswe/PS1基因小鼠比非转基因小鼠具有更高的易怒水平。此外，在强迫游泳实验中，APPswe/PS1小鼠的筑巢能力比对照组差，且静止时间更长。这些结果与阿尔茨海默病模型中冷漠和抑郁样行为增加的假设一致。此外，APPswe/PS1基因小鼠在被动回避学习和左右辨别学习的保留上存在缺陷，这与之前在其他阿尔茨海默样模型中的发现一致。
Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models.