In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia.
In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia.
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DOI：
10.1039/b900880b
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发表时间：
2009-10
影响因子：
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通讯作者：
Kazuto Watanabe;M. Harada‐Shiba;A. Suzuki;Risa Gokuden;Ryohsuke Kurihara;Yusuke Sugao;Takeshige Mori;Y. Katayama;T. Niidome
中科院分区：
文献类型：
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作者：
Kazuto Watanabe;M. Harada‐Shiba;A. Suzuki;Risa Gokuden;Ryohsuke Kurihara;Yusuke Sugao;Takeshige Mori;Y. Katayama;T. Niidome
静脉内递送载脂蛋白B特异性siRNA与第六代树枝状聚（L-赖氨酸）（KG 6）导致siRNA介导的敲除健康C57 BL/6小鼠中的ApoB，而无肝毒性，并且载脂蛋白E缺陷小鼠的血清低密度脂蛋白胆固醇显著降低。
Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.