Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium 1. Fermentation and biological characteristics
Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium 1. Fermentation and biological characteristics
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DOI：
10.7164/antibiotics.54.149
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发表时间：
2001-02-01
影响因子：
3.3
通讯作者：
Yamanaka, S
中科院分区：
文献类型：
--
作者：
Fudou, R;Iizuka, T;Yamanaka, S
从海洋粘细菌的培养液中分离得到一种新的含共轭四烯结构的β-甲氧基丙烯酸酯类抗生素--海良菌素。一株暂命名为Haliangium luteum的细菌需要2 ~ 3%NaCl才能生长和产生Haliangicin。海良菌素抑制广谱真菌的生长，但对细菌无活性。在线粒体呼吸链中，haliangicin干扰细胞色素b-c1段内的电子流动。
Haliangicin, a novel beta -methoxyacrylate antibiotic with a conjugated tetraene moiety, was isolated from the culture broth of a marine myxobacterium. A bacterium tentatively named as Haliangium luteum required 2 similar to3% NaCl for the growth and production of haliangicin. Haliangicin inhibits the growth of a wide spectrum of fungi but was inactive against bacteria. In mitochondrial respiratory chains, haliangicin interfered the electron flow within the cytochrome b-c1 segment.