Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease
Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease
复制标题
DOI：
10.1016/j.jacc.2003.07.042
复制
发表时间：
2004-01-21
影响因子：
24
通讯作者：
Bank, AJ
中科院分区：
文献类型：
--
作者：
Kaiser, DR;Billups, K;Bank, AJ
本研究的目的是确定血管性勃起功能障碍（艾德）患者和无其他临床心血管疾病的患者是否具有其他血管beds.Background的结构和功能异常，在许多艾德患者中，血管疾病是主要的潜在原因。它可能是艾德是动脉粥样硬化的早期标志物在患者没有临床cardiovascular diseases.METHODS我们评估了全身血管结构和功能在30例艾德和27名年龄匹配的正常对照（NL）科目。我们测量了血管参数，包括：1）颈动脉和肱动脉直径，内膜中层厚度，顺应性和扩张性; 2）主动脉脉搏波速度; 3）冠状动脉钙化;和4）肱动脉内皮依赖性和非依赖性vasodilation.RESULTS有两组之间的基线人口统计学，冠状动脉风险评分，或血脂值没有显着差异。艾德和NL组的大多数结构和功能血管参数相似。与NL受试者相比，艾德患者的肱动脉血流介导的血管舒张（FMD）（1.3 vs. 2.4%，p = 0.014）和硝酸甘油（NTG）的血管舒张（13.0 vs. 17.8%，p < 0.05）显著降低。此外，艾德患者FMD与NTG引起的血管舒张反应有显著相关性（r = 0.59，结论：艾德患者无临床心血管疾病，但内皮依赖性和非内皮依赖性的外周血管缺陷，在其他明显的功能性或结构性全身性血管疾病发生之前发生的独立血管舒张，并且与其他血管疾病无关。传统的心血管危险因素。(C)2004年，美国心脏病学会基金会。
OBJECTIVES The goal of this study was to determine whether patients with vascular erectile dysfunction (ED) and no other clinical cardiovascular disease have structural and functional abnormalities of other vascular beds.BACKGROUND In many ED patients, vascular disease is the major underlying cause. It may be that ED is an early marker of atherosclerosis in patients without clinical cardiovascular disease.METHODS We assessed systemic vascular structure and function in 30 patients with ED and 27 age-matched normal control (NL) subjects. We measured vascular parameters, including: 1) carotid and brachial artery diameters, intima-media thickness, compliance, and distensibility; 2) aortic pulse wave velocity; 3) coronary calcification; and 4) brachial artery endothelium-dependent and -independent vasodilation.RESULTS There were no significant differences in baseline demographics, coronary artery risk score, or lipid values between the two groups. Most structural and functional vascular parameters were similar in the ED and NL groups. Brachial artery flow-mediated vasodilation (FMD) (1.3 vs. 2.4%, p = 0.014) and vasodilation to nitroglycerin (NTG) (13.0 vs. 17.8%, p < 0.05) were significantly reduced in ED patients, compared with NL subjects. In addition, there was a significant correlation between FMD and vasodilation to NTG in ED patients (r = 0.59, p < 0.05) but not in NL subjects.CONCLUSIONS Patients with ED but no clinical cardiovascular disease have a peripheral vascular defect in endothelium-dependent and -independent vasodilation that occurs before the development of other overt functional or structural systemic vascular disease and is independent of other traditional cardiovascular risk factors. (C) 2004 by the American College of Cardiology Foundation.