Melanocortin-4 receptor-regulated energy homeostasis.
Melanocortin-4 receptor-regulated energy homeostasis.
复制标题
Melanocortin-4 受体调节的能量稳态。
DOI：
10.1038/nn.4202
复制
发表时间：
2016-02
影响因子：
25
通讯作者：
Garfield AS
中科院分区：
文献类型：
--
作者：
Krashes MJ;Lowell BB;Garfield AS
黑素皮质素系统为能量状态的中央控制提供了一个概念性的蓝图。由四个主要分子成分-两个拮抗作用的配体和两个同源受体-定义的这个系统进化保守的系统作为分级能量平衡调节的原型。在过去的十年中，条件基因技术的应用促进了对黑素皮质素能网络的神经解剖解剖，并确定了特定的神经底物和回路，强调了对摄食行为、能量消耗、葡萄糖动态平衡和自主神经流出的调节。在这一点上，黑素皮质素-4受体是哺乳动物能量平衡和体重的重要协调者。借鉴神经科学和基因技术的最新进展，我们考虑黑素皮质素-4受体电路的结构和功能及其在能量平衡中的作用。
The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural substrates and circuits that underscore the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow. In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis.