Enhanced selectivity for the hydrolysis of block copoly(2-oxazoline)s in ethanol-water resulting in linear poly(ethylene imine) copolymers.
Enhanced selectivity for the hydrolysis of block copoly(2-oxazoline)s in ethanol-water resulting in linear poly(ethylene imine) copolymers.
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DOI：
10.1002/marc.201200046
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发表时间：
2012-05
影响因子：
4.6
通讯作者：
Huub P. C. van Kuringen;V. R. de la Rosa;Martin W. M. Fijten;J. Heuts;R. Hoogenboom
中科院分区：
文献类型：
--
作者：
Huub P. C. van Kuringen;V. R. de la Rosa;Martin W. M. Fijten;J. Heuts;R. Hoogenboom
将聚(2-恶唑啉)S和聚乙二亚胺的性质融合在一起的能力在各种生物医学应用中引起了极大的兴趣，包括基因传递、生物传感器和可切换的表面和纳米颗粒。本研究建立了乙醇-水混合溶剂中(Co)聚(2-恶唑啉)S(POX-PEI)可控选择性水解的方法学，为合成具有可调性能的嵌段聚(2-恶唑啉-共乙烯亚胺)(POX-PEI)共聚物开辟了道路。在追求定义明确的POX-PEI嵌段共聚物的过程中，所选择的乙醇-水二元溶剂混合物对水解动力学和选择性的意外影响被突出显示。
The ability of merging the properties of poly(2-oxazoline)s and poly(ethylene imine) is of high interest for various biomedical applications, including gene delivery, biosensors, and switchable surfaces and nanoparticles. In the present research, a methodology for the controlled and selective hydrolysis of (co)poly(2-oxazoline)s is developed in an ethanol-water solvent mixture, opening the path toward a wide range of block poly(2-oxazoline-co-ethylene imine) (POx-PEI) copolymers with tunable properties. The unexpected influence of the selected ethanol-water binary solvent mixture on the hydrolysis kinetics and selectivity is highlighted in the pursue of well-defined POx-PEI block copolymers.