Prevalence of essential tremor in three elderly populations of Central Spain
Prevalence of essential tremor in three elderly populations of Central Spain
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DOI：
10.1002/mds.10376
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发表时间：
2003-04-01
影响因子：
8.6
通讯作者：
Molina, JA
中科院分区：
文献类型：
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作者：
Benito-León, J;Bermejo-Pareja, F;Molina, JA
尽管特发性震颤（ET）被认为是最常见的成人运动障碍，但全球关于其患病率和分布的现有信息尚未完全了解。我们采用逐户两阶段方法调查了西班牙三个老年人群中ET的患病率和分布情况。1994年5月1日，对来自大马德里一个城市自治市（赫塔菲的玛格丽塔斯区）、马德里一个城区（利斯塔）和一个农村地区（阿维拉的阿雷瓦洛县）的64岁以上人群（共5278人）使用了一种简易筛查工具。研究对象限于筛查呈阳性者（472人）。为提高可靠性，每位患者由3名经验丰富的神经科医生检查，只有当3名神经科医生意见一致时才被归类为患有ET（472人中的183人）。本研究是一项大规模神经系统疾病流行病学调查的一部分，并作为一项为期3年的发病率研究的基线调查。因此，在评估痴呆、中风或帕金森病筛查呈阳性但震颤筛查呈阴性的受试者时，发现了41例ET患者；此外，在第二次横断面研究（1997年5月1日）中评估震颤筛查呈阳性但在第一次横断面研究中震颤筛查呈阴性的受试者时，又发现了32例额外的ET患病病例。我们确定了256人（152名女性，104名男性）患有ET；其中，87名患者（34.0%）报告有患病亲属。204名（79.7%）ET患者是通过此次筛查发现的，且此前未被诊断过。ET在总人群中的患病率为4.8%（95%置信区间 = 4.2 - 5.4）；男性为4.6%（95%置信区间 = 3.7 - 5.4），女性为5.0%（95%置信区间 = 4.2 - 5.8）。男性和女性的年龄别患病率均随年龄增长而增加。尽管全球数据存在差异，但ET是老年人中常见的疾病。此外，由于ET可能被视为一种相对良性的疾病，很大一部分患者可能从未寻求过神经科治疗。（C）2002运动障碍学会
Although essential tremor (ET) is considered the most prevalent adult movement disorder, the available information on its prevalence and distribution worldwide is not completely understood. We investigated the prevalence and distribution of ET in three elderly Spanish populations using a door-to-door, two-phase approach. A brief screening instrument was administered on May 1, 1994 to subjects over 64 years old taken from the census of one urban municipality of Greater Madrid (quarter of Margaritas, Getafe), one urban district of Madrid (Lista), and one rural site (Arevalo county, Avila) (N = 5,278). Study subjects were limited to those who screened positively (N = 472). To increase reliability, each patient was examined by 3 experienced neurologists, and was classified as having ET only when all 3 neurologists agreed (183 of 472). The present study was part of a large-scale epidemiological survey of neurological diseases, and served as a baseline investigation in a 3-year incidence study. Accordingly, 41 ET patients were identified when evaluating subjects who had screened positively for dementia, stroke, or parkinsonism, despite the fact that they had screened negatively for tremor; furthermore, 32 additional ET prevalent cases were detected when evaluating subjects who had screened positively for tremor in the second cross-sectional study (May 1, 1997), although they had screened negatively for tremor in the first cross-sectional study. We identified 256 persons (152 women, 104 men) with ET; of these, 87 patients (34.0%) reported having an affected relative. Two hundred and four (79.7%) of the subjects with ET were detected through this screening and had not been diagnosed previously. The prevalence of ET was 4.8% (95% CI = 4.2-5.4) for the total population; 4.6% (95% Cl = 3.7-5.4) in men and 5.0% (95% CI = 4.2-5.8) in women. Age-specific prevalence increased with advancing age for both men and women. Despite the variability in worldwide data, ET is a frequently encountered disorder in elderly people. Furthermore, as ET may be seen as a relatively benign condition, a large proportion of patients may never seek neurological attention. (C) 2002 Movement Disorder Society.