Isolation and Identification of a Sulfakinin-Like Peptide, with Sequence Homology to Vertebrate Gastrin and Cholecystokinin, from the Brain of Locusta Migratoria

Isolation and Identification of a Sulfakinin-Like Peptide, with Sequence Homology to Vertebrate Gastrin and Cholecystokinin, from the Brain of Locusta Migratoria
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飞蝗大脑中与脊椎动物胃泌素和胆囊收缩素具有序列同源性的磺胺激肽样肽的分离和鉴定

DOI:
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发表时间:
1990
期刊:
影响因子:
--
通讯作者:
A. Loof
A. Loof
中科院分区:
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文献类型:
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作者:
L. Schoofs;M. Holman;T. K. Hayes;A. Loof

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从 9000 个飞蝗脑复合体的提取物中分离出一种神经肽 (pGlu-Leu-Ala-Ser-Asp-Asp-Tyr-Gly-His-Met-Arg-Phe-NH2),其 N 末端被封闭,且与来自马德拉蟑螂的无色硫磺素 I 和 II 相关。该肽刺激蟑螂后肠的蠕动。通过高效液相色谱纯化过程中通过观察柱级分对分离的现代白藻后肠的肌向作用来监测生物活性。
A neuropeptide (pGlu-Leu-Ala-Ser-Asp-Asp-Tyr-Gly-His-Met-Arg-Phe-NH2) with a blocked N-terminus and related to leucosulfakinins I and II from the Madeira roach has been isolated from an extract of 9000 brain complexes of Locusta migratoria. The peptide stimulates the motility of the cockroach hindgut. Biological activity was monitored during purification by high performance liquid chromatography by observing the myotropic effect of column fractions on the isolated hindgut of Leucophaea moderne.
DOI: --
发表时间: 1988
期刊: The Journal of biological chemistry
影响因子: --
作者:
Nichols,R;Schneuwly,SA;Dixon,JE
通讯作者: Dixon,JE