High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis
High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis
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DOI：
10.1093/humrep/17.10.2715
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发表时间：
2002-10-01
影响因子：
6.1
通讯作者：
Stratton, P
中科院分区：
文献类型：
--
作者：
Sinaii, N;Cleary, SD;Stratton, P
背景：子宫内膜异位症患者也可能有与自身免疫失调或疼痛相关的疾病。本研究检测了子宫内膜异位症患者自身免疫性疾病、慢性疼痛、疲劳和特应性疾病的患病率是否高于一般女性人群。方法和结果：1998年，子宫内膜异位症协会对3680名手术诊断为子宫内膜异位症的美国会员进行了一项横断面调查。几乎所有的反应者都有疼痛（99%），许多人报告不孕症（41%）。与美国一般女性人群中公布的发病率相比，子宫内膜异位症女性的甲状腺功能减退率更高（9.6 vs 1.5%，P < 0.0001），纤维肌痛（5.9%对3.4%，P < 0.0001），慢性疲劳综合征（4.6%对0.03%，P < 0.0001），类风湿性关节炎（1.8 vs 1.2%，P = 0.001），系统性红斑狼疮（0.8比0.04%，P < 0.0001），干燥综合征（0.6比0.03%，P < 0.0001）和多发性硬化（0.5比0.07%，P < 0.0001），但不包括甲亢和糖尿病。过敏和哮喘在子宫内膜异位症患者中更为常见纤维肌痛组和慢性疲劳综合征组分别为61%和12%（P < 0.001在美国女性人群中，乳腺癌的发生率（分别为88%，P < 0.001和25%，P < 0.001）高于乳腺癌的发生率（分别为18%，P < 0.001和5%，P < 0.001）。结论：甲状腺功能减退症，纤维肌痛，慢性疲劳综合征，自身免疫性疾病，过敏和哮喘在子宫内膜异位症女性中比在美国普通人群中更常见。
BACKGROUND: Women with endometriosis may also have associated disorders related to autoimmune dysregulation or pain. This study examined whether the prevalence of autoimmune, chronic pain and fatigue and atopic disorders is higher in women with endometriosis than in the general female population. METHODS AND RESULTS: A cross-sectional survey was conducted in 1998 by the Endometriosis Association of 3680 USA members with surgically diagnosed endometriosis. Almost all responders had pain (99%), and many reported infertility (41%). Compared with published rates in the general USA female population, women with endometriosis had higher rates of hypothyroidism (9.6 versus 1.5%, P < 0.0001), fibromyalgia (5.9 versus 3.4%, P < 0.0001), chronic fatigue syndrome (4.6 versus 0.03%, P < 0.0001), rheumatoid arthritis (1.8 versus 1.2%, P = 0.001), systemic lupus erythematosus (0.8 versus 0.04%, P < 0.0001), Sjogren's syndrome (0.6 versus 0.03%, P < 0.0001) and multiple sclerosis (0.5 versus 0.07%, P < 0.0001), but not hyperthyroidism or diabetes. Allergies and asthma were more common among women with endometriosis alone (61%, P < 0.001 and 12%, P < 0.001 respectively) and highest in those with fibromyalgia or chronic fatigue syndrome (88%, P < 0.001 and 25%, P < 0.001 respectively) than in the USA female population (18%, P < 0.001 and 5%, P < 0.001 respectively). CONCLUSIONS: Hypothyroidism, fibromyalgia, chronic fatigue syndrome, autoimmune diseases, allergies and asthma are all significantly more common in women with endometriosis than in women in the general USA population.