Projections from the laterodorsal nucleus of the thalamus to the limbic and visual cortices in the rat.
Projections from the laterodorsal nucleus of the thalamus to the limbic and visual cortices in the rat.
复制标题
大鼠丘脑外侧核到边缘皮层和视觉皮层的投射。
DOI：
10.1002/cne.903240310
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Wyss,JM
中科院分区：
文献类型：
--
作者：
vanGroen,T;Wyss,JM
丘脑背外侧核（LD）是丘脑传入边缘皮质的重要来源，但这些投射的地形和分层尚未详细研究。利用菜豆白细胞凝集素和Fluoro-Ruby的顺行运输，本研究表明，在大鼠中，LD投射到放射下区、中央前无颗粒区、压后区、视觉（18 b区）、下托和内嗅皮质。LD的每个子区域在这些皮质区域内具有不同的终端模式。LD的吻侧部和背侧部密集地投射到压后颗粒a（Rga）皮质、前下托和旁下托。背侧LD的尾部略多，主要投射到后下托。LD的更多腹侧部分主要投射到压后颗粒异常（Rdg）和压后颗粒B（Rgb）皮质。LD向18 b区的投射来源于LD尾侧部的细胞。在每个皮质区域，LD终端显示不同的层状模式。在区域18 b和相邻的Rdg皮质中，LD终末场位于I、III和IV层中，但在Rgb和Rga皮质中，终末场主要位于I层中。在后下托中，LD终末分布于I层和III/IV层，并延伸至浅层V;在前下托和旁下托中，LD终末仅分布于深层（即，层IV-VI）。少量的LD轴突终止于深层（即，层IV-VI）。这些结果表明，LD的每个区域都有一个独特的边缘和相邻的新皮层的投影。
The laterodorsal nucleus (LD) of the thalamus is an important source of thalamic afferents to the limbic cortex, but the topography and lamination of these projections has not been investigated in detail. Using the anterograde transport ofPhaseolus vulgarisleucoagglutinin and Fluoro‐Ruby, the present study demonstrates that in the rat, LD projects to infraradiata, precentral agranular, retrosplenial, visual (area 18b), subicular, and entorhinal cortices. Each subregion of LD has a distinct pattern of terminals within these cortical areas. The rostral part and the dorsalmost part of LD project densely to retrosplenial granular a (Rga) cortex, presubiculum and parasubiculum. Slightly more caudal parts of dorsal LD project primarily to the postsubiculum. More ventral parts of LD project primarily to retrosplenial dysgranular (Rdg) and retrosplenial granular b (Rgb) cortices. The projection of LD to area 18b originates from cells in the caudalmost part of LD. In each cortical region, LD terminals display distinct laminar patterns. In area 18b and the adjacent Rdg cortex, the LD terminal field is in layers I, III, and IV, but in both the Rgb and Rga cortices the terminal field is located predominantly in layer I. In the postsubiculum the LD terminals are distributed to layers I and III/IV and extend into superficial layer V; in the presubiculum and the parasubiculum the LD terminals are only in the deep layers (i.e., layers IV–VI). A small number of LD axons terminate in the deep layers (i.e., layers IV–VI) of the medial entorhinal cortex. These results indicate that each area of LD has a distinct projection to limbic and adjacent neocortex.