Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol.
Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol.
复制标题
选择性阻断内皮素 A 亚型受体可减少饲喂胆固醇的仓鼠的早期动脉粥样硬化。
DOI：
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发表时间：
1995
影响因子：
6
通讯作者：
Stephen K. Durham
中科院分区：
文献类型：
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作者：
M. Kowala;Patricia M. Rose;D. Philip;Stein;Nancy Goller;R. Recce;Sophie Beyer;M. Valentine;Debbie Barton;Stephen K. Durham
最近的研究表明内皮素及其受体可能参与动脉粥样硬化形成。为了检验这一假设，用选择性内皮素 A 亚型 (ETA) 受体拮抗剂 BMS-182874 治疗饲喂胆固醇的仓鼠。仓鼠动脉粥样硬化斑块的特征表明，它们含有平滑肌细胞的纤维帽、大巨噬细胞泡沫细胞和氧化低密度脂蛋白的表位。在主动脉内皮细胞、内侧平滑肌细胞、巨噬细胞泡沫细胞和纤维脂肪斑块的平滑肌细胞中检测到了 ETA 和 ETB 受体的信使 RNA。 BMS-182874 抑制内皮素 1 诱导的升压反应，而降压作用未改变，表明血管 ETA 受体在体内被选择性阻断。在高脂血症仓鼠中，BMS-182874 通过减少巨噬细胞泡沫细胞的数量和大小来减少脂肪条纹的面积。结果表明，ETA 受体和内皮素促进了动脉粥样硬化的早期炎症阶段。
Recent studies suggest that endothelin and its receptors may be involved in atherogenesis. To test this hypothesis, cholesterol-fed hamsters were treated with a selective endothelin subtype A (ETA) receptor antagonist BMS-182874. Characterization of hamster atherosclerotic plaques indicated that they contained a fibrous cap of smooth muscle cells, large macrophage-foam cells, and epitopes of oxidized low density lipoprotein. Messenger RNA for both ETA and ETB receptors was detected in aortic endothelial cells, in medial smooth muscle cells, and in macrophage-foam cells and smooth muscle cells of the fibro-fatty plaques. BMS-182874 inhibited the endothelin-1-induced pressor response whereas the depressor effect was unaltered, suggesting that vascular ETA receptors were selectively blocked in vivo. In hyperlipidemic hamsters, BMS-182874 decreased the area of the fatty streak by reducing the number and size of macrophage-foam cells. The results indicated that ETA receptors and thus endothelin promoted the early inflammatory phase of atherosclerosis.
DOI：
10.1161/01.atv.10.3.336
发表时间：
1990-05-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
ROSENFELD, ME;PALINSKI, W;WITZTUM, JL
通讯作者：
WITZTUM, JL