Skin cancers amongst four Nigerian albinos
Skin cancers amongst four Nigerian albinos
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DOI：
10.1111/j.1365-4632.2009.04017.x
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发表时间：
2009-06-01
影响因子：
3.6
通讯作者：
Bassey, Ekpo E.
中科院分区：
文献类型：
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作者：
Asuquo, Maurice E.;Ngim, Ogbu;Bassey, Ekpo E.
背景白化病是一个既定的危险因素，皮肤癌在非洲黑人，高水平的紫外线辐射增加的三种主要形式的皮肤cancer.Methods的风险，我们提出了四个白化病皮肤癌的组织学诊断谁被认为是在卡拉巴尔大学教学医院，卡拉巴尔，尼日利亚从2005年1月至2006年12月。皮肤癌在这些情况下进行了比较，总的皮肤癌影响29例患者在研究期间。四名尼日利亚白化病患者（两名男性和两名女性）患有皮肤癌，占2年期间观察到的皮肤癌的13.8%。年龄22 ~ 40岁，平均27.8岁。病变部位包括头部[2例患者为鳞状细胞癌（SCC），1例患者为基底细胞癌（BCC）]和上肢（黑色素瘤）。切除所有肿瘤;此外，SCC和黑色素瘤患者接受辅助化疗。两名患者，一名妇女与SCC和黑色素瘤患者，显示残留肿瘤，因为不充分的切除。在14 ~ 18个月的评估期内，男性SCC和女性BCC的部位似乎愈合，无复发迹象。结论白化病和太阳辐射是皮肤癌的危险因素。及早实施关于预防的公众教育战略应能改善结果。
Background Albinism is an established risk factor for skin cancer in black Africans, and high levels of ultraviolet radiation increase the risk of the three major forms of skin cancer.Methods We present four albinos with histologic diagnoses of skin cancer who were seen at the University of Calabar Teaching Hospital, Calabar, Nigeria from January 2005 to December 2006. Skin cancer in these cases was compared with the total skin cancer affecting 29 patients during the study period.Results Twenty-nine patients presented with skin cancer during the study period. Four Nigerian albinos ( two men and two women) with skin cancer accounted for 13.8% of the skin cancers observed during the 2-year period. They ranged in age from 22 to 40 years ( mean, 27.8 years). The sites of the lesions included the head [ squamous cell carcinoma (SCC) in two patients and basal cell carcinoma (BCC) in one patient] and the upper limb ( melanoma). All tumors were excised; in addition, patients with SCC and melanoma received adjuvant chemotherapy. Two patients, one woman with SCC and the patient with melanoma, showed residual tumor because of inadequate excision. During the evaluation period between 14 and 18 months, the sites appeared to be healed with no evidence of recurrence in the male with SCC and female with BCC.Conclusion Albinism and solar radiation are risk factors for skin cancer. Early implementation of public education strategies on prevention should improve outcome.