Morphological development and fate of the mouse mesonephros.
Morphological development and fate of the mouse mesonephros.
复制标题
小鼠中肾的形态发育和命运。
作者：
Colin Smith;Sarah Mackay
对小鼠中肾小管的发育进行了一项研究，以探究肾小管上皮细胞向性腺体细胞和/或肾上腺皮质细胞可能的转分化。进行了层粘连蛋白的免疫组织化学定位，以研究基膜的发育。在性腺原基的体细胞聚集期间，中肾小管腹侧的细胞未显示上皮表型；仅在此期间之后，基膜才在腹侧出现。因此，没必要假定这些细胞发生转分化。
A study has been made of the development of mesonephric tubules in the mouse to investigate the possible transdifferentiation of tubule epithelial cell to gonadal somatic cells and/or adrenal cortical cells. Immunohistochemical localisation of laminin was carried out to study the development of basal laminae. Cells at the ventral aspect of mesonephric tubules did not show an epithelial phenotype during the period of somatic cell population of the gonadal blastema; a basal lamina appeared ventrally only after this period. Therefore, it is not necessary to postulate transdifferentiation of these cells.