Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses
Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses
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DOI：
10.1016/j.biomaterials.2008.01.030
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发表时间：
2008-05-01
期刊：
影响因子：
14
通讯作者：
Chauhan, Anuj
中科院分区：
文献类型：
--
作者：
Kim, Jinah;Conway, Anthony;Chauhan, Anuj
我们开发了长时间佩戴的硅水凝胶软性隐形眼镜，它可以在几周到几个月的时间内提供眼科药物。以不同的单体配比制备了N，N-二甲基丙烯氧基丙基（三甲基硅氧基）硅烷、二- α、- omega（甲基丙烯氧基）聚二甲基硅氧烷、1-乙烯基-2-吡咯烷酮、乙二醇二甲基丙烯酸酯等有机硅水凝胶，并对三种不同眼科药物噻莫洛尔、地塞米松和21-醋酸地塞米松的转运进行了探讨。所有0.1 mm厚度的硅酮水凝胶都表现出扩散受限的运输和延长释放，根据硅酮水凝胶的疏水和亲水组分的组成，从20天到3个月不等。此外，至少某些分子的运输存在多个时间尺度，这可能是由于这些凝胶的复杂微观结构。镜片的机械和物理性能，如离子渗透性、平衡含水量、透明度和一些凝胶的表面接触角，适合隐形眼镜应用。(C) 2008 Elsevier Ltd版权所有。
We developed extended wear silicone hydrogel soft contact lenses that deliver ophthalmic drugs for an extended period of time ranging from weeks to months. Silicone hydrogels comprising of N,N-dimethylacrylamide, 3-methacryloxypropyltris(trimethylsiloxy)silane, bis-alpha, omega(methacryloxypropyl) polydimethylsiloxane, 1-vinyl-2-pyrrolidone, and ethylene glycol dimethacrylate were prepared with varying ratios of monomers and transport of three different ophthalmic drugs, timolol, dexamethasone, and dexamethasone 21-acetate was explored. All the silicone hydrogels of 0.1 mm thickness exhibit diffusion limited transport and extended release varying 20 days up to more than three months depending on the compositions of hydrophobic and hydrophilic components of silicone hydrogels. Also, there are multiple time scales in transport of at least certain molecules, which is perhaps due to the complex microstructure of these gels. The mechanical and physical properties of lenses such as ion permeability, equilibrium water content, transparency, and surface contact angles of some of the gels are suitable for contact lens application. (C) 2008 Elsevier Ltd. All rights reserved.