The contribution of autophagy to lymphocyte survival and homeostasis.
The contribution of autophagy to lymphocyte survival and homeostasis.
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DOI：
10.1111/j.1600-065x.2012.01143.x
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发表时间：
2012-09
影响因子：
8.7
通讯作者：
He YW
中科院分区：
文献类型：
--
作者：
McLeod IX;Jia W;He YW
在T淋巴细胞的整个生命周期中，从胸腺发育到死亡，它受到各种压力和刺激。在接受每一个压力或刺激时，必须做出一个可能改变生命的命运决定，即是否致力于某种形式的程序性细胞死亡，或者做出必要的适应以有效地应对不断变化的环境。在我们的实验室中，我们已经确定了T淋巴细胞在正常寿命期间会遇到的几种压力。我们的研究集中在T细胞如何利用自噬来掌握情况，或者在生存无法维持的情况下，T细胞如何利用自噬来加速它们的死亡。本文综述了T细胞自噬在维持体内平衡，消除过量或危险水平的线粒体，修整内质网水平，促进健康的代谢水平，使细胞能够作为免疫系统的生产性组成部分的功能。此外，将讨论使用自噬信号分子来执行涉及维持免疫稳态的自噬独立任务。
Over the life span of a T lymphocyte, from thymic development to death, it is subjected to a variety of stresses and stimuli. Upon receipt of each stress or stimulus, a potentially life-changing fate decision must be made, namely, whether to commit to a form of programmed cell death or to make the necessary adaptations to effectively deal with the changing environment. In our laboratory, we have identified several stresses that a T lymphocyte will encounter during a normal life span. Our studies have focused on how T cells utilize autophagy to get a grasp on the situation, or in cases in which survival is untenable, how T cells use autophagy to hasten their demise. This review focuses on the functions of T-cell autophagy in maintaining homeostasis, eliminating excess or dangerous levels of mitochondria, trimming levels of endoplasmic reticulum, and promoting a healthy metabolic level to allow cells to perform as productive components of the immune system. Additionally, the use of autophagy signaling molecules to perform autophagy-independent tasks involved in the maintenance of immune homeostasis will be discussed.