Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro
Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro
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DOI：
10.3109/14653249.2010.529890
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发表时间：
2011-04-01
期刊：
影响因子：
4.5
通讯作者：
Kohmoto, Takushi
中科院分区：
文献类型：
--
作者：
Lushaj, Entela B.;Anstadt, Emily;Kohmoto, Takushi
背景目标。多年来，人类心脏一直被认为是一个终末分化的器官，在损伤后没有再生的潜力。然而，最近的研究对这一由来已久的教条产生了怀疑。本研究的目的是研究成年小鼠心脏中间充质基质细胞(MSC)的存在和特征。并分析了MSC对成体心肌干细胞生长分化的影响。方法：研究方法。谱系阴性/c-kit阴性的组合(LINE
Background aims. For many years the human heart has been considered a terminally differentiated organ with no regenerative potential after injury. Recent studies, however, have cast doubt on this long-standing dogma. The objective of this study was to investigate the presence of and characterize mesenchymal stromal cells (MSC) in the adult mouse heart. The impact of MSC on growth and differentiation of adult cardiac stem cells (CSC) was also analyzed. Methods. A combination of lineage-negative/c-kit-negative (Lin