SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women.
SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women.
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DOI：
10.1016/j.jri.2021.103464
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Franco A
中科院分区：
文献类型：
--
作者：
Hsieh LE;Grifoni A;Dave H;Wang J;Johnson D;Zellner J;Sidney J;Chambers C;Franco A
我们研究了8名恢复期孕妇对SARS-CoV-2刺突和非刺突肽表位的T细胞应答，以及免疫监测，包括对维持免疫母/胎界面至关重要的先天性致耐受性树突状细胞群，以解决妊娠结局中抗病毒细胞应答的潜在风险。4名受试者有可能影响SARS-CoV-2特异性T细胞反应的预先存在的慢性炎症状况。8名受试者中有7名对SARS-CoV-2肽有反应，但CD4 + T辅助细胞（Th）和CD8+细胞毒性T细胞（CTL）存在差异。SARS-CoV-2特异性可诱导调节性T细胞（iTreg）在循环中数量众多。CD4 + T细胞记忆包括中央记忆T细胞（TCM）和效应记忆T细胞（TEM）。就CD8+记忆库而言，TCM和TEM在8名受试者中非常低或不存在，并且只有恢复为CD45RA+的效应细胞（定义为TEMRA）在循环中是可测量的。T细胞在所有受试者中均在正常范围内，无论预先存在的炎症状况如何。免疫表型表明包括CD14 + cDC 2和CD4 + ILT-4 + tmDC的致耐受性骨髓树突状细胞的扩增和活化。总之，SARS-CoV-2感染在孕妇中诱导生理性抗病毒T细胞应答，包括SARS-CoV-2特异性iTreg，对与母胎界面免疫稳态相关的致耐受性先天树突状细胞库没有负面影响。所有8名受试者都分娩了健康的足月婴儿。
We studied the T cell response to SARS-CoV-2 spike and non-spike peptide epitopes in eight convalescent pregnant women together with the immune monitoring that included innate tolerogenic dendritic cell populations important to maintain the immunological mother/fetus interface to address a potential risk for the antiviral cellular response in the outcome of pregnancy. Four subjects had pre-existing chronic inflammatory conditions that could have potentially affected the SARS-CoV-2-specific T cell response. Seven of eight subjects responded to SARS-CoV-2 peptides with differences within CD4+ T helper (Th) and CD8+ cytotoxic T cells (CTL). SARS-CoV-2-specific inducible regulatory T cells (iTreg) were numerous in circulation. CD4+ T cell memory included central memory T cells (TCM) and effector memory (TEM). As far as the CD8+ memory repertoire, TCM and TEM were very low or absent in eight of eight subjects and only effector cells that revert to CD45RA+, defined as TEMRA were measurable in circulation. T cells were in the normal range in all subjects regardless of pre-existing inflammatory conditions. The immune phenotype indicated the expansion and activation of tolerogenic myeloid dendritic cells including CD14+ cDC2 and CD4+ ILT-4+ tmDC. In summary, SARS-CoV-2 infection induced a physiological anti-viral T cell response in pregnant women that included SARS-CoV-2-specific iTreg with no negative effects on the tolerogenic innate dendritic cell repertoire relevant to the immune homeostasis of the maternal-fetal interface. All eight subjects studied delivered full-term, healthy infants.
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影响因子：
10.1
作者：
Amodio, Giada;Comi, Michela;Gregori, Silvia
通讯作者：
Gregori, Silvia
影响因子：
7.3
作者：
Gregori S;Amodio G;Quattrone F;Panina-Bordignon P
通讯作者：
Panina-Bordignon P
影响因子：
3.7
作者：
Chambers, Christina D.;Johnson, Diana L.;Jones, Kenneth Lyons
通讯作者：
Jones, Kenneth Lyons
DOI：
10.15585/mmwr.mm6938e1
发表时间：
2020-09-25
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Delahoy MJ;Whitaker M;O'Halloran A;Chai SJ;Kirley PD;Alden N;Kawasaki B;Meek J;Yousey-Hindes K;Anderson EJ;Openo KP;Monroe ML;Ryan PA;Fox K;Kim S;Lynfield R;Siebman S;Davis SS;Sosin DM;Barney G;Muse A;Bennett NM;Felsen CB;Billing LM;Shiltz J;Sutton M;West N;Schaffner W;Talbot HK;George A;Spencer M;Ellington S;Galang RR;Gilboa SM;Tong VT;Piasecki A;Brammer L;Fry AM;Hall AJ;Wortham JM;Kim L;Garg S;COVID-NET Surveillance Team
通讯作者：
COVID-NET Surveillance Team
DOI：
10.1038/s41577-020-00460-4
发表时间：
2020-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Lipsitch M;Grad YH;Sette A;Crotty S
通讯作者：
Crotty S