Supramolecular Chemotherapy: Cooperative Enhancement of Antitumor Activity by Combining Controlled Release of Oxaliplatin and Consuming of Spermine by Cucurbit[7]uril
Supramolecular Chemotherapy: Cooperative Enhancement of Antitumor Activity by Combining Controlled Release of Oxaliplatin and Consuming of Spermine by Cucurbit[7]uril
复制标题
DOI：
10.1021/acsami.7b01157
复制
发表时间：
2017-03-15
影响因子：
9.5
通讯作者：
Zhang, Xi
中科院分区：
文献类型：
--
作者：
Chen, Yueyue;Huang, Zehuan;Zhang, Xi
超分子化疗是利用超分子途径调节肿瘤细胞毒作用，提高抗肿瘤药物疗效的一种化疗方法。本文介绍了一种新的超分子化学疗法，即利用临床抗癌药物奥沙利铂（奥沙利铂是治疗结直肠癌的特异性药物）。奥沙利铂与葫芦[7]脲（CB[7]）的主客体络合作用可显著降低奥沙利铂对结直肠正常细胞的细胞毒性。更重要的是，奥沙利铂-CB [7]表现出协同增强的抗肿瘤活性，优于奥沙利铂本身。一方面，奥沙利铂的抗肿瘤活性可以通过竞争性取代奥沙利铂-CB中的精胺而重现[7];另一方面，CB[7]可以消耗肿瘤环境中过表达的精胺，这对肿瘤细胞生长至关重要。这两个事件可以导致协同增强的抗肿瘤性能。超分子化疗可用于治疗精胺过度表达的肿瘤。这一策略有望应用于其他抗肿瘤药物的研究，为超分子化学治疗开辟了新的前景。
Supramolecular chemotherapy is aimed to employ supramolecular approach for regulating the cytotoxicity and improving the efficiency of antitumor drugs. In this paper, we demonstrated a new example of supramolecular chemotherapy by utilizing the clinical antitumor drug, oxaliplatin, which is the specific drug for colorectal cancer treatment. Cytotoxicity of oxaliplatin to the colorectal normal cell could be significantly decreased by host guest complexation between oxaliplatin and cucurbit[7]uril (CB[7]). More importantly, oxaliplatin-CB[7] exhibited cooperatively enhanced antitumor activity than oxaliplatin itself. On the one hand, the antitumor activity of oxaliplatin can reappear by competitive replacement of spermine from oxaliplatin-CB[7]; on the other hand, CB[7] can consume the overexpressed spermine in tumor environments, which is essential for tumor cell growth. These two events can lead to the cooperatively enhanced antitumor performance. Supramolecular chemotherapy can be applied to treat with spermine-overexpressed tumors. It is highly anticipated that this strategy may be employed in many other clinical antitumor drugs, which opens a new horizon of supramolecular chemotherapy for potential applications in clinical antitumor treatments.