TRAF1-C5 as a risk locus for rheumatoid arthritis - A genomewide study
TRAF1-C5 as a risk locus for rheumatoid arthritis - A genomewide study
复制标题
DOI：
10.1056/nejmoa073491
复制
发表时间：
2007-09-20
影响因子：
158.5
通讯作者：
Gregersen, Peter K.
中科院分区：
文献类型：
--
作者：
Plenge, Robert M.;Seielstad, Mark;Gregersen, Peter K.
背景rheumatoid关节炎具有复杂的遗传模式。尽管HLA-DRB1和PTPN22是公认的敏感性基因座，但最近已经确定了赋予适度风险水平的其他基因。我们进行了全基因组的关联分析，以鉴定与类风湿关节炎风险增加有关的其他遗传基因座。Methodswe基因分型317,503个单核苷酸多态性（SNP）在1522名伴有rhe剂匹配的对照对照对象的病例受试者的联合病例控制中， 。患者对抗粉状柠檬酸肽（CCP）的自身抗体的血清阳性。我们从两个数据集中获得了样品，即北美类风湿关节炎联盟（NARAC）和瑞典风湿关节炎（EIRA）的瑞典流行病学研究。通过质量控制过滤器的297,086个SNP的NARAC和EIRA的结果与使用Cochran-Mantel-Haenszel分层分析结合使用。 SNP与疾病有显着关联（P
BackgroundRheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis.MethodsWe genotyped 317,503 single-nucleotide polymorphisms (SNPs) in a combined case-control study of 1522 case subjects with rheumatoid arthritis and 1850 matched control subjects. The patients were seropositive for autoantibodies against cyclic citrullinated peptide (CCP). We obtained samples from two data sets, the North American Rheumatoid Arthritis Consortium (NARAC) and the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Results from NARAC and EIRA for 297,086 SNPs that passed quality-control filters were combined with the use of Cochran-Mantel-Haenszel stratified analysis. SNPs showing a significant association with disease (P