A Pooled Analysis of Diagnostic Value of 99mTc-Ubiquicidin (UBI) Scintigraphy in Detection of an Infectious Process
A Pooled Analysis of Diagnostic Value of 99mTc-Ubiquicidin (UBI) Scintigraphy in Detection of an Infectious Process
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DOI：
10.1097/rlu.0b013e3182867d56
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发表时间：
2013-06-01
影响因子：
10.6
通讯作者：
Assadi, Majid
中科院分区：
文献类型：
--
作者：
Ostovar, Afshin;Assadi, Mahsan;Assadi, Majid
目的：虽然技术-99m泛素（Tc-99m-UBI）扫描技术在检测人类感染方面的有限研究数据很有希望，但这些研究的样本量有限。本研究旨在对Tc-99m-UBI闪烁成像在检测感染过程中的诊断准确性进行系统回顾和荟萃分析。材料与方法：系统检索PubMed/MEDLINE、Web of Science、EMBASE、谷歌Scholar等文献数据库，查找Tc-99m-UBI的相关人类研究。对于每个符合条件的研究，记录Tc-99m-UBI闪烁成像的真阳性、假阳性、真阴性和假阴性结果，并获得总体统计参数。结果：2004 - 2010年共纳入10项研究。合并数据敏感性为94.5%，95%置信区间为91.2% ~ 96.8%。合并特异性仍高达约92.7%。报告的特异性范围从80%到100%。总体准确率为93.7% （95% CI: 91.2% ~ 95.7%）。结论：研究表明，Tc-99m-UBI闪烁显像可用于早期识别感染过程，具有较高的准确性；然而，建议进一步调查。
Purpose: Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-99m-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-99m-UBI scintigraphy in detection of an infectious process.Materials and Methods: The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-99m-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-99m-UBI scintigraphy were recorded, and the overall statistical parameters were acquired.Result: Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5% and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%).Conclusion: The study demonstrated that Tc-99m-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.