Origin of the neocortical subependymal cells speculated by Emx1 and GAD67 expression.
Origin of the neocortical subependymal cells speculated by Emx1 and GAD67 expression.
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DOI：
10.1093/chemse/bjh139
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发表时间：
2005
期刊：
影响因子：
3.5
通讯作者：
N. Tamamaki
中科院分区：
文献类型：
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作者：
N. Tamamaki
自从小鼠端脑中的成体神经发生被广泛描述和接受以来，已经过去了十多年。成体神经发生归因于齿状回颗粒下层和端脑室管膜下层的前体细胞。然而，齿状回和室管膜下层的前体细胞的发育起源尚不清楚。众所周知，胚胎大脑中的神经发生发生在脑室带(VZ)。最近，有人提出端脑VZ的前体细胞转变为室下区(SVZ)星形胶质细胞(Tramontin等人，2003)。新皮质室管膜下层被认为是成人嗅球颗粒细胞和球周细胞的来源。室管膜下层产生的神经元作为吻端的迁移流迁移到嗅球，新产生的神经元将成为嗅球中的GABA能抑制神经元。然而，我们认为新皮质VZ细胞转变为SVZ星形胶质细胞，然后产生GABA能神经元的想法是不连续的。到目前为止，众所周知，大多数新皮质GABA能神经元是由起源于苍白球下结构的切向细胞迁移提供的(Anderson等人，1997；Tamamaki等人，1997)。也有人推测，新皮质VZ几乎缺乏产生GABA能神经元的能力。在这种情况下，我们推测嗅球的GABA能神经元可能是由新皮质以外的前体细胞产生的。在本文中，我们将证明成年新皮质中的室管膜下细胞是异质性的，可能有不同的来源。
More than a decade has passed since adult neurogenesis in the murine telencephalon was described and accepted widely. The adult neurogenesis has been attributed to the progenitors in the subgranular layer in the dentate gyrus and the subependymal layer of the telencephalon. However, the developmental origin of the progenitors in the dentate gyrus and the subependymal layer is poorly understood. It is well known that the neurogenesis in the embryo brains occurs in the ventricular zone (VZ). Recently it has been proposed that the progenitors in the VZ of the telencephalon turn into the subventricular zone (SVZ) astrocytes (Tramontin et al., 2003). The subependymal layer of the neocortex has been regarded as a source of the granule cells and periglomerular cells in the adult olfactory bulb. The subependymal layer produces neurons that migrate to the olfactory bulb as the rostral migratory stream, and the newly produced neurons are going to be GABAergic inhibitory neurons in the olfactory bulb. However, we felt discontinuity in the idea that the neocortical VZ cells turn into SVZ astrocytes and then produce GABAergic neurons. By now, it is well known that most of the neocortical GABAergic neurons were supplied by tangential cell migration originating in the subpallial structures (Anderson et al., 1997; Tamamaki et al., 1997). It is also speculated that the neocortical VZ almost lack the ability to produce GABAergic neurons. Under these circumstances, we speculated that the GABAergic neurons for the olfactory bulb may be produced by progenitors derived from other than the neocortex. In this paper we will show that the subependymal cells in the adult neocortex are heterogeneous and may have different origin.