Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer.
Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer.
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DOI：
10.1155/2016/4549676
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发表时间：
2016
影响因子：
4.6
通讯作者：
Schwertfeger KL
中科院分区：
文献类型：
--
作者：
Brady NJ;Chuntova P;Schwertfeger KL
巨噬细胞是炎症的重要介质和发育过程的重要调节因子。巨噬细胞作为一种关键的吞噬细胞类型，作为先天免疫系统的一部分进化而来，吞噬和处理细胞碎片和病原体。巨噬细胞产生直接作用于其微环境的因子，并在先天免疫应答和适应性免疫系统之间架起桥梁。巨噬细胞作为组织损伤的传感器和维持组织稳态是重要的。现在已经确定巨噬细胞是乳腺肿瘤微环境的一个组成部分，在那里它们有助于肿瘤的生长和进展，可能通过许多在正常伤口愈合反应中使用的机制。由于巨噬细胞有助于正常乳腺发育和乳腺癌的生长和进展，本综述将讨论常驻乳腺巨噬细胞和肿瘤相关巨噬细胞，重点描述巨噬细胞在正常发育和癌症背景下如何与周围环境相互作用。
Macrophages are critical mediators of inflammation and important regulators of developmental processes. As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens. Macrophages produce factors that act directly on their microenvironment and also bridge innate immune responses to the adaptive immune system. Resident macrophages are important for acting as sensors for tissue damage and maintaining tissue homeostasis. It is now well-established that macrophages are an integral component of the breast tumor microenvironment, where they contribute to tumor growth and progression, likely through many of the mechanisms that are utilized during normal wound healing responses. Because macrophages contribute to normal mammary gland development and breast cancer growth and progression, this review will discuss both resident mammary gland macrophages and tumor-associated macrophages with an emphasis on describing how macrophages interact with their surrounding environment during normal development and in the context of cancer.