Impact of Internet pharmacy regulation on opioid analgesic availability
Impact of Internet pharmacy regulation on opioid analgesic availability
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DOI：
10.15288/jsad.2008.69.703
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发表时间：
2008-09-01
影响因子：
3.4
通讯作者：
Wines, James D., Jr.
中科院分区：
文献类型：
--
作者：
Boyer, Edward W.;Wines, James D., Jr.
目标：处方阿片类镇痛药的获取使互联网药店成为监管审查加强的对象，但监管变化在减少在线来源阿片类镇痛药的供应方面的有效性尚未得到评估。作为对互联网与药物滥用之间关系的持续调查的一部分，我们检查了在线药店处方阿片类镇痛药的可用性。方法：我们从一个药房观察网站构建了一个自 2005 年 11 月 1 日起每 3 个月输入一次的帖子数据集，这些帖子与处方阿片类镇痛药的购买有关。训练有素的审查员评估了最终帖子描述的止痛药的可及性是否增加或减少。结果：我们确定了 45 条与互联网药房阿片类镇痛药供应情况相关的线索。在描述互联网药房阿片类镇痛药供应量下降的 41 条 (91%) 帖子中，有 34 条 (82%) 于 2007 年 11 月 1 日收到帖子。尽管研究问题具有主观性，但编码员之间观察者间的一致性很高 (K = .845)，认为在线药房阿片类镇痛药的供应量有所下降。这一发现得到了描述阿片类镇痛药可用性下降的网页浏览量（衡量网站访问者对页面内容兴趣的公认衡量标准）数量急剧上升的支持。结论：这些数据表明处方阿片类镇痛药物的供应量显着下降。这种自我报告的药品供应变化可能与针对互联网药店的监管和执法行动的加强有关。
Objective: Access to prescription opioid analgesics has made Internet pharmacies the object of increased regulatory scrutiny, but the effectiveness of regulatory changes in curtailing availability of opioid analgesics from online sources has been not assessed. As part of an ongoing investigation into the relationship between the Internet and substance abuse, we examined the availability of prescription opioid analgesics from online pharmacies. Method: From a pharmacy watch Web site, we constructed a data set of postings entered every 3 months beginning November 1, 2005, that were related to the purchase of prescription opioid analgesics. Trained examiners assessed whether the final post described accessibility of pain medications that was increasing or decreasing. Results: We identified 45 threads related to the availability of opioid analgesics from Internet pharmacies. Of the 41 (91%) threads describing the declining availability of opioid analgesic agents from Internet pharmacies, 34 (82%) received posts on November 1, 2007. Despite the subjective nature of the research question, there was high interobserver agreement between coders (K = .845) that availability of opioid analgesics from online pharmacies had decreased. This finding was supported by a dramatic rise in the number of pageviews (an accepted measure of Web site visitor interest in a page's content) of Web pages describing decreased availability of opioid analgesics. Conclusions: These data suggest striking decreases in the availability of prescription opioid analgesic pharmaceuticals. This self-reported change in drug availability may be related to increased regulation of and law enforcement operations directed against Internet pharmacies.