The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage
The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage
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DOI：
10.1158/1078-0432.ccr-07-1610
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发表时间：
2007-11-15
影响因子：
11.5
通讯作者：
Nirodi, Chaitanya S.
中科院分区：
文献类型：
--
作者：
Chen, David J.;Nirodi, Chaitanya S.
表皮生长因子受体(EGFR)是肿瘤对电离辐射反应的重要决定因素，常在上皮性肿瘤中表达。在患者中，EGFR表达和活性的升高常常与肿瘤对放疗的抵抗有关。EGFR被认为通过激活生存和细胞增殖途径来增强肿瘤对辐射的抵抗力。最近的发现发现了一种新的EGFR的辐射防护功能，它涉及到辐射诱导的受体核移位及其与DNA依赖的蛋白激酶的相互作用，DNA依赖的蛋白激酶是非同源末端连接DNA修复途径的关键组成部分。靶向EGFR的DNA修复功能可作为肿瘤对放射治疗增敏的一种治疗模式。
The epidermal growth factor receptor (EGFR), which is frequently expressed in tumors of epithelial origin, is an important determinant of tumor responses to ionizing radiation. Elevated EGFR expression and activity frequently correlate with tumor resistance to radiotherapy in patients. EGFR is thought to confer tumor resistance to radiation through the activation of survival and cell proliferation pathways. Recent discoveries have identified a novel radioprotective function of EGFR which involves the radiation-induced nuclear translocation of the receptor and its interactions with the DNA-dependent protein kinase, a key component of the nonhomologous end-joining DNA repair pathway. Targeting the DNA repair function of EGFR may serve as a therapeutic model for sensitizing tumors to radiotherapy in patients.